Background: Acrochordon is a benign fibroepithelial skin tumor commonly found in intertriginous areas and thought to be associated with insulin resistance (IR). Hyperinsulinemia resulting from IR contributes to fibroblast and keratinocyte proliferation through activation of the insulin-like growth factor-1 signaling pathway. The homeostatic model assessment of insulin resistance (HOMA-IR) is a …
Latar Belakang; Prevalensi terjadinya defisiensi Vitamin D pada penderita luka kaki diabetes cukup tinggi. Defisiensi vitamin D dapat menyebabkan hambatan penyembuhan luka. Vitamin D berperan sebagai regulator proliferasi sel dan pengaturan inflamasi. Proliferasi dan perbaikan jaringan melibatkan peran matrix metalloproteinase-9 (MMP-9) dan tissue inhibitor matrix metalloproteinase-1 (TIMP-1) s…
The development of an interactive learning media assisted by Google Sites on the topic of plane figures for fourth-grade elementary school students SDN 10 Talang Kelapa aims to determine the development stages, assess the validity level, and evaluate the media practicality. This study employed the Research and Development (R&D) method using the ADDIE model, which consists of the Analyze, Design…
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Type 2 diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from insulin resistance and pancreatic β-cell dysfunction. Limitations of conventional therapies, which may cause adverse effects, have encouraged the development of antidiabetic agents derived from natural products. Paliasa leaves (Kleinhovia hospita Linn.) are known to contain bioactive compound…
Type 2 diabetes is a chronic disease that requires early detection to reduce the risk of complications. This study aims to design a web-based prototype Clinical Decision Support System (CDSS) to predict diabetes risk using the XGBoost algorithm and improve interpretability through the SHAP method. The dataset used was obtained from Kaggle and consisted of approximately 100,000 records with eigh…
The prevalence of type 2 diabetes mellitus in adults continues to increase, but the relationship between age, anxiety levels, and quality of life still shows varying results. This study aims to determine the relationship between age and anxiety levels with the quality of life of type 2 diabetes mellitus patients. This study used a quantitative method with a correlational design. The sample cons…