Morus alba L. is a plant from Moraceae family which is found in tropical and subtropical areas. M. alba plant was reported to have displayed several bioactivities such as antioxidant, antitumor, antibacterial, anticancer, antidiabetic, and anti-inflammatory. M. alba plant has a diversity of secondary metabolites. This research was aimed to isolate and identify secondary metabolite compounds fro…
Sungkai (Peronema canescens Jack.) is one of woody plants which is usually found in the Southern part of Sumatra which is often used as an herbal plant by people for flu and fever. This research was aimed to know immunomodulator potency of Sungkai in mice (Mus muculus) and effect extract to proliferation of Saccharomyces cerevisiae yeast and leukocytes. Yeast proliferation is associated with in…
Gastritis is a disease caused by inflammation of the gastric mucosa characterized by pain, swelling, and irritation of the gastric mucous membrane. One of the Pharmacological therapy for managing gastritis involves H2 receptor antagonists, Ranitidine. For treating gastritis, a 150-300mg dose is administered once or twice a day. Rational drug use involves administering medication according to th…
Staphylococcus aureus is one of the most commonly exposed bacteria and causes infection in humans. Efforts that can be made in medicine are using antibiotics. The use of antibiotics has recently been irrational and has led to antibiotic resistance. Efforts that can be made to prevent resistance are using alternative medicine. Alternative medicine that can be used is plants. Avocado leaves are h…
Background. Shigellosis is a clinical condition caused by invasion of Shigella species in the epithelium lining the terminal ileum, colon and rectum. Efforts that can be made to treat shigellosis are using fluoroquinolone antibiotics. However, cases of resistance of patients infected by Shigella to fluoroquinolone antibiotics have been reported to have increased in the Southeast Asian. This stu…
Background: Thalassemia is a hereditary hemolytic disease that is an autosomal recessive, characterized by a disorder in hemoglobin synthesis. The management of thalassemia, particularly major thalassemia, includes regular blood transfusions and iron chelation therapy to control iron accumulation. The iron level in the body can be determined through a common examination, which is the serum ferr…
Bitter leaf extract (Andrographis paniculate (Burm.f) Wall. Ex Ness) contains secondary metabolites andrographolide and quercetin which have potential antibacterial activity. This research aims to determine the nanoemulsion formulation with a combination of Tween 80 and Ethanol 96% concentration on the activity of Propionibacterium acnes and the stability of ICH Q1A (R2). Data analysis in this …
Sambiloto leaves (Andrographis paniculate (Burm. F) Wall ex. Ness) contain andrografolid and flavonoids as the main compounds that have potential as antibacterial. Nanoemulsion with a combination of tween 20 and PEG-400 was carried out to produce preparations that have better antibacterial effects and are thermodynamically stable. This study was conducted to determine the characteristics and st…
Tuberculosis is a contagious respiratory tract infection caused by Mycobacterium tuberculosis. This research utilized an in silico approach to predict the molecular potential of target compounds in oregano leaves (Origanum vulgare L.) for antituberculosis activity. The potential compounds in oregano leaves included phytol, carvacrol, γ-terpinene, p-cymene, and cyclotetradecane. The SwissADME d…
Latar Belakang: Sindrom koroner akut (SKA) merupakan kelompok penyakit yang meliputi angina tidak stabil, NSTEMI dan STEMI, serta merupakan salah satu diagnosis yang sering ditemukan pada ruang IGD. Troponin T umumnya digunakan untuk diagnosis, serta skor grace sebagai prognosis pasien SKA. Sayangnya pemeriksaan tersebut tidak bisa dilakukan kepada semua orang karena pemeriksaan tersebut belum …
Ekstrak daun sukun (Artocarpus altilis (Parkinson) Fosberg) mengandung senyawa metabolit sekunder utama flavonoid dan fenolik. Penelitian ini bertujuan untuk mengetahui optimum konsentrasi Tween 80 dan Etanol 96% dalam sediaan nanoemulsi ekstrak etanol daun sukun. Optimasi dilakukan dengan desain faktorial 22 menggunakan Design Expert 12®. Formula optimum yang diperoleh selanjutnya dilakukan k…
Clindamycin HCl as a topical anti-acne drug has low bioavailability due to its hydrophilic nature which is difficult to penetrate the stratum corneum. Propionibacterium acnes, the main pathogen of acne, lives in the sebaceous glands in the dermis, so it requires deeper penetration. Transethosomes can increase penetration because they are classified as lipid nanovesicles with good elasticity and…
Wounds or damage to part of the body tissue if not treated immediately will cause infection and even death. Plants that can help the wound healing process include alpha mangostin compounds from mangosteen skin (Garcinia mangostana L.). Optimization of active substance delivery is carried out in the form of transdermal patch preparations. This study aims to obtain the optimum formula for transde…
Dyspepsia is a condition of discomfort that persists (episodic) or experiences recurrence of pain in the upper abdomen, nausea, vomiting, bloating, fullness, fullness of the stomach, and pain in the epigastrium. with an incidence proportion of 35.5% in Palembang City in 2015. Rational use of dyspepsia medication is very important to ensure that the medication given is appropriate, safe, and eff…
Mangosteen peel extract has an alfa-mangosteen compound that can accelerate cell healing by stimulating fibroblast growth, thus providing effects as an anti�inflammatory and antimicrobial. The choice of transdermal patch dosage form for mangosteen peel extract aims to effectively deliver active substances through the skin to reach the systemic. The purpose of this study was to obtain a formul…
Daun singkong (Manihot Esculenta Crantz.) mengandung senyawa metabolit yang dihasilkan salah satunya flavonoid terdapat rutin dikenal sebagai quercetin-3-rutinoside yang berpotensi sebagai anti acne. Etosom memiliki kemampuan sebagai pengantar untuk meningkatkan transfer bahan aktif melalui kulit dengan lebih efisien dalam hal permeabilitas kulit. Tujuan dari penelitian ini adalah mengetahui fo…
The Purple golden leaves (Ruellia tuberosa L.) contain secondary metabolites in the form of flavonoid compounds which have antioxidant activity which can act as a hepatoprotector. This study aims to determine the hepatoprotective activity of ethanol extract of purple golden leaves (Ruellia tuberosa L.) in male Wistar white rats induced by CCl4 based on parameters measuring SGOT, SGPT and ALP le…
The grasshopper has a tendency to eat plant leaves, causing physical damage such as tears in the leaves, and can even cause the loss of all leaves. One way to deal with the presence of locusts is by using sungkai leaf bioinsecticide (Peronema canescens) which contains poison for locusts. The purpose of this study was to determine the effect of sungkai leaf extract and the optimal concentration …
A poor lifestyle can lead to the accumulation of free radicals that trigger degenerative diseases. Natural antioxidant compounds are needed to reduce free radical molecules formed in the body. One source of natural antioxidants comes from the kuku elang plant (Oxyceros longiflorus (Lam.) T. Yamaz.). The research methods used are extraction, fractionation, antioxidant activity test of fractions …
The leaves of the kencana ungu (Ruellia tuberosa L.) contains flavonoid compounds potentially as diuretics. This study aims to determine the diuretic activity of ethanol extract of kencana ungu leaves. Diuretic activity testing was carried out on 6 groups of test animals including normal (aquades), negative (NaCMC), positive (Furosemide), and three groups of treatment doses of 100, 200 and 400 …
Cassava leaves contain rutin compounds which are flavonoid derivatives that have antibacterial properties. Transdermal patch preparation was chosen for the ethyl acetate fraction of cassava leaves because it can produce effective preparations to deliver active compounds through the skin to reach the systemic. This study aims to obtain the best formula with plasticizer concentration in transderm…
Fraksi etil asetat daun singkong mengandung senyawa rutin yang efektif menghambat pertumbuhan bakteri Staphylococcus aureus. Penelitian ini bertujuan mengetahui variasi konsentrasi kalsium klorida sebagai crosslinker terhadap transdermal patch yang dihasilkan dan mengetahui aktivitas antibakteri sediaan transdermal patch. Polimer yang digunakan pada penelitian ini adalah kitosan dan natrium alg…
Kanker payudara adalah kelainan pada payudara yang berupa tumor karena proliferasi sel. Penelitian ini bertujuan memprediksi potensi molekuler dari senyawa daun Clinacanthus nutans terhadap aktivitas antiproliferasi kanker payudara dengan pendekatan bioinformatika. Ekstrak yang memiliki senyawa potensi ditelaah interaksi molekulernya. Basis data pkCSM menampilkan profil ADMET tiap senyawa. Basi…
Setelah sukses dengan buku `atlas tumbuhan obat indonesia` jilid 1 dan 2, kini kami hadirkan jilid 3 untuk melengkapi pengetahuan anda tentang berbagai tumbuhan yang memiliki khasiat obat. selain dilengkapi foto yang menunjang, uraian yang detail dan jelas akan membuat Anda mudah memahami isi buku ini. Segera simak semua informasi penting yang terangkum dalam buku ini dan ciptkan keluarga, masy…
Setelah Bertahun- tahun mendewakan obat modern yang memang bereaksi cepat kini, orang kembali melirik obat alami. Selain karena kesadaran akan resiko efek samping juga karena krisis ekonomi yang tak terelakkan. Untuk itulah, kami hadirkan buku ini untuk anda.
Background: Hyperuricemia is describes a condition where serum uric acid levels increase above normal values. Hyperuricemia occurs due to increased production and excretion of uric acid in the kidneys. The first line of treatment for reducing uric acid levels is xanthine oxidase inhibitors, allupurinol and febuxostat. However, many people use traditional medicine derived from natural plants. On…