Background. Pulmonary tuberculosis (TB) is a chronic infectious disease that remains a major health concern in Indonesia. Its prolonged inflammatory process can affect serum protein levels, particularly albumin and globulin. Based on current theoretical evidence, albumin functions as a negative acute-phase protein that decreases during inflammation and malnutrition, whereas globulin increases a…
Background: Stunting remains a nutritional problem among children under five in Indonesia. National data in 2024 reported a prevalence of 19.8%, indicating that the condition has not been fully resolved. Maternal knowledge about stunting plays an essential role in its prevention by shaping awareness, attitudes, and behaviors related to maintaining children’s health and nutritional needs for o…
Background. Laryngopharyngeal reflux (LPR) is a condition in which gastric contents reflux into the larynx and pharynx, resulting in symptoms such as globus sensation, chronic cough, dysphagia, and voice changes. These symptoms can substantially impair patients’ quality of life. This study aims to describe the quality of life of patients with LPR using the Laryngopharyngeal Reflux–Health-Re…
Background. Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by inflammation and multi-organ involvement. Its management requires a long-term multidisciplinary approach, which poses challenges for patients to maintain medication adherence. Poor adherence often leads to inadequate disease control, as reflected by higher disease activity, and worsened prognosis. T…
Background: Leukemia is a hematologic malignancy arising from the abnormal proliferation of immature leukocytes. It ranks as the 13th most frequently diagnosed cancer and the 10th leading cause of cancer-related death worldwide. Based on proliferation rate and cell lineage, leukemia is classified as acute or chronic, and as myeloid or lymphoid. Laboratory examination, cytomorphologic and cytoch…
Background. Osteosarcoma is the most common primary malignant bone tumor, particularly occurring in children, adolescents, and young adults. One of the genes that plays an important role in the pathogenesis of osteosarcoma is TP53, a tumor suppressor gene that regulates the cell cycle and apoptosis. Mutation or disruption of the expression of this gene causes loss of the ability to inhibit abno…
Background: Syphilis is a sexually transmitted infection caused by Treponema pallidum with an increasing trend in both global and national cases. This study is important to determine the incidence rate and the relationship between demographic profiles and risky sexual behavior in syphilis patients at the Dermatology, Venereology, and Aesthetics (DVE) Polyclinic of Mohammad Hoesin Hospital Palem…
Background. Thyroid heart disease (THD) is a cardiovascular disorder arising from thyroid dysfunctionhyperthyroidism or hypothyroidismwhich may cause palpitations and arrhythmias associated with systolic or diastolic dysfunction. This may progress to complication such as heart failure and increased mortality. Epidemiological data in Indonesia remains limited. Therefore, this study aimed t…
Background. Acute appendicitis is the most common cause of emergency abdominal surgery, yet its diagnosis remains difficult due to nonspecific early symptoms, leading to a 15–20% misdiagnosis rate. Although the Alvarado score is widely used and generally reliable, its accuracy varies across populations, potentially affecting surgical decisions. This study aimed to assess the relationship betw…
Background: Preterm birth is one of the leading causes of neonatal morbidity and mortality. The proportion of preterm births at Dr. Mohammad Hoesin General Hospital, Palembang, is relatively high, highlighting the need to identify maternal risk factors associated with preterm delivery in order to guide prevention strategies. Methods: This was an analytic observational study with a case–contro…
Background: Deaf children generally rely more on nonverbal communication, such as sign language, to interact. Sign language plays an important role in enhancing communication skills and social integration, thus it needs to be taught from an early age. The role play method offers a more interactive and participatory approach, allowing children to learn through direct experience and improve their…
Background: Adolescents are at risk of experiencing hormonal disturbances due to imbalanced nutritional status, in which excessive body mass index (BMI) may increase androgen levels and insulin resistance, while low BMI may reduce estrogen levels, thereby affecting menstrual cycle regularity and increasing sebum production that triggers acne vulgaris. This study aims to determine the relationsh…
Pendahuluan: Talasemia beta mayor merupakan kelainan genetik yang ditandai dengan gangguan pembentukan rantai β-globin sehingga menyebabkan anemia berat yang memerlukan transfusi darah rutin seumur hidup. Transfusi darah berulang dapat menimbulkan kelebihan zat besi (iron overload) yang ditandai dengan meningkatnya kadar ferritin serum. Peningkatan kadar ferritin yang tidak terkontrol dapat me…
Background: Cervical cancer is a malignancy highly influenced by Human Papillomavirus (HPV) infection, especially types 16 and 18. In Indonesia, cervical cancer cases and mortality remain high, while HPV vaccination coverage as a primary prevention effort is still suboptimal, particularly because parental decisions strongly affect child immunization. Lack of adequate knowledge and attitudes tow…
Background. Prostate cancer and benign prostatic hyperplasia (BPH) are the most common prostate disorders in elderly men, often presenting with similar clinical manifestations. Measurement of Prostate-Specific Antigen (PSA) levels plays an important role in the early detection of prostate abnormalities, although elevated PSA is not specific for malignancy. Due to limited local data on PSA level…
Background : Urinary Tract Infection (UTI) is one of the pregnancy risk factors caused by bacterial infection which, if not properly managed, can worsen pregnancy outcomes. Various risk factors such as age, socioeconomic status, education level, parity, frequency of sexual intercourse, number of pregnancies, history of UTI, and body mass index may influence the occurrence of UTI. This study aim…
Background. Coffee consumption is a common habit among medical students to improve concentration and cope with academic stress. Caffeine in coffee can affect sleep quality through adenosine receptor antagonism. This study aims to determine the relationship between coffee consumption patterns and sleep quality disturbances among medical students, Sriwijaya University, Class of 2022. Method. This…
Background: Obstructive sleep apnea (OSA) is a sleep disorder caused by airway obstruction, which reduces oxygen supply and increases the risk of chronic disease. In Indonesia, its prevalence is unknown due to limited data and limited medical personnel knowledge. Therefore, it is necessary to assess their knowledge and attitudes towards OSA at Dr. Mohammad Hoesin General Hospital, Palembang. Me…
Background: Preterm delivery remains one of the leading causes of neonatal morbidity and mortality. One contributing factor is maternal iron status, particularly iron deficiency anemia (IDA). Hematological parameters such as Hb, MCV, MCHC, RDW, as well as the Mentzer and Green-King indices, can serve as early indicators of iron status disturbances in pregnant women. Methods: This descriptive cr…
Background: Nosocomial infections remain a major problem with high incidence rates globally and in Indonesia, contributing to morbidity and mortality, especially with the increasing antibiotic resistance including Serratia marcescens, a multidrug-resistant organism and a common Gram-negative pathogen in ICUs. Indonesia is rich in herbal plants, one of which is karamunting leaf (Rhodomyrtus tome…
Background: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder in women of reproductive age that is often accompanied by insulin resistance. Purple sweet potato (Ipomoea batatas L.) is known to contain anthocyanins and flavonoids that function as antidiabetics. This study aims to determine the effectiveness of purple sweet potato extract on insulin resistance in a PCOS mouse model base…
Introduction: Myocardial infarction (MI) is a leading cause of global mortality with reperfusion therapy as its the gold standard. However, the following myocardial ischemia-reperfusion injury (MIRI) still lacks effective pharmacologic treatment. Mapping protein interaction networks may help identify herbal-based therapeutic targets related to mitochondria which holds central role in energy met…
Penyakit infeksi masih merupakan penyakit utama di banyak negara berkembang, termasuk Indonesia; terutama infeksi saluran pernafasan akut (ISPA) dengan yang tersering adalah rinitis simpleks, faringitis, tonsilitis, dan sinusitis. Bakteri yang dapat menyebabkan faringitis antara lain streptokokus grup A, korinebakterium, arkanobakterium, atau Chlamydia pneumoniae. Selain itu, dapat juga terjadi…
Terdapat enam belas tipe kepribadian yang dimiliki oleh manusia menurut Teori Psikologi Jung yang dikembangkan oleh Myers-Briggs. Tipe kepribadian itu adalah ISTJ, ISFJ, INFJ, INTJ, ISTP, ISFP, INFP, INTP, ESTP, ESFP, ENFP, ENTP, ESTJ, ESFJ, ENFJ, dan ENTJ. Tujuan penelitian ini adalah untuk mengidentifikasi distribusi frekuensi tipe kepribadian mahasiswa Fakultas Kedokteran Universitas Sriwija…
Asma bronkial adalah penyakit saluran napas kronik yang penting dan merupakan masalah kesehatan yang serius di berbagai Negara di seluruh dunia. Oleh sebab itu, penanganannya memerlukan perhatian yang serius. Pemberian obat pada pasien asma bronkial harus memperhatikan kemungkinan interaksi yang teijadi, karena resep yang tidak rasional dapat lebih memperberat penyakit. Penelitian berupa survei…
Hipertrofi ventrikel kiri (HVK) merupakan respon awal jantung terhadap hipertensi yang tidak terkontrol yang secara fisiologis merupakan proses kompensasi jantung terhadap peningkatan tahanan perifer dengan meningkatkan beban jantung (afterload). Akan tetapi dengan peningkatan beban terhadap pompa jantung yang berlangsung lama dan massa batas toleransi hipertrofi ventrikei kiri yang terlewati, …
Penyakit diare merupakan salah satu penyebab utaina yang banyak menimbulkan kematian dan kesakitan pada masa anak-anak di negara sedang berkembang. Diperkirakan 1000 juta kasus diare terjadi setiap tahun pada anak balita, dengan perkiraan 5 juta kematian terjadi setiap tahunnya. Sekitar 80% kematian ini tcijadi pada dua tahun pertama kehidupan anak. Hingga ini penyakit diare atau sering juga di…