ABSTRACT Background: Lumbar spinal stenosis is a degenerative condition characterized by narrowing of the spinal canal, leading to pain and neurological deficits. Inflammatory processes are thought to play a key role in its pathogenesis, with increased levels of inflammatory mediators such as C-Reactive Protein (CRP) and Interleukin-1β (IL-1β). However, the correlation between these biomarker…
Background: The first thousand days of life is a period from the beginning of pregnancy until two years of age. Dental caries is a microbiological disease of the hard dental tissues caused by the interaction of bacteria that produce acids through carbohydrate fermentation, resulting in demineralization of inorganic substances and destruction of the organic structure of the teeth. Objective: Thi…
Introduction:Breast carcinoma is the most common breast malignancy among women in Indonesia,accounting for 30.8% of female cancer cases in 2020, with high prevalence at Dr. Mohammad Hoesin General Hospital (20.9% in 2019–2020). Serum calcium plays a crucial role in cellular regulation of cancer through homeostasis of PTH, vitamin D, and mechanisms such as PTHrP and local osteolysis, where hyp…
Latar belakang: Fraktur pelvis merupakan cidera pada struktur cincin pelvis, yang dapat melibatkan tulang ilium, ischium, pubis, sakrum, atau kombinasi dari beberapa bagian tersebut. Penelitian ini bertujuan untuk mengetahui hubungan faktor-faktor risiko pasien fraktur pelvis dengan mortalitas. Metode: Desain penelitian deskriptif dalam bentuk serial kasus. Seluruh kasus fraktur pelvis di RSUP …
This dissertation is motivated by the disharmony between accelerated economic development and the preservation of environmental functions in Indonesia. The current Environmental Protection and Management (PPLH) legal system is considered to be dominated by a rigid anthropocentric and positivistic paradigm, often failing to capture the moral values and wisdom living within society. This study ai…
Law No. 16 of 2025 on the Fourth Amendment to Law No. 19 of 2003 recognizes Alternative Dispute Resolution (ADR) through deliberation and mediation, with agreements that are final and binding for the parties in dispute. However, this regulation only applies to disputes between state-owned enterprises (SOEs), while disputes between SOEs and Private-Owned Enterprises (POEs) are not regulated for …
Background: Lung cancer is a malignant tumor originating from lung tissue, including the respiratory epithelium. It is one of the leading causes of cancer-related mortality worldwide and is frequently diagnosed at an advanced stage with a poor prognosis. Systemic inflammation and nutritional status play important roles in disease progression and patient survival. The modified Glasgow Prognostic…
Background The prognosis of advanced-stage lung cancer remains poor despite ongoing therapeutic advances. Systemic inflammation and nutritional status are increasingly recognized as important prognostic determinants. The Advanced Lung Cancer Inflammation Index (ALI) is a prognostic parameter that evaluates the degree of systemic inflammation by combining body mass index (BMI), serum albumin lev…
Background: Dental caries was one of the most common chronic diseases among schoolaged children, with prevalence rates of 84.8% in children aged 5–9 years and 63.8% in those aged 10–14 years based on the 2023 Indonesian Health Survey. High consumption of added sugar and low levels of knowledge regarding its impact on oral health were identified as contributing factors. This condition highli…
Background: Parental knowledge plays an important role in maintainingoral health of children with physical disabilities who have motor limitations anddepend on parents for dental care. Objective: To analyze the relationship betweenparents’ level of knowledge and dental caries in children with physical disabilitiesat SLB D YPAC Palembang City. Methods: A descriptive-analytical quantitativestud…
Background: Dental anxiety is a primary barrier in pediatric dental care that causes treatment refusal and poor oral health. The Tell-Play-Do (TPD) method using a smartphone dentist game is a modification of conventional behavior management that potentially reduces anxiety through interactive education and distraction. Objective: This study aims to determine the effect of the TPD behavior manag…
Background: Oral health in visually impaired children required special attention because visual limitations could affect their ability to maintain oral hygiene independently, increasing the risk of plaque accumulation and oral diseases. The selection of toothbrush type and proper brushing technique were important factors in controlling plaque in these manual and sonic electric toothbrushes in v…
Latar belakang: Coronary Artery Bypass Graft (CABG) adalah prosedur bedah jantung yang dapat memengaruhi hasil pascaoperasi, termasuk lama perawatan di ICU Kardiovaskular (CV ICU). Durasi CPB dan waktu klem aorta (AoX) yang berkepanjangan diduga berhubungan dengan peningkatan morbiditas serta perpanjangan masa perawatan pascaoperasi. Tujuan: Menentukan hubungan antara lama CPB dan waktu AoX den…
Background Hemorrhagic stroke is a neurological condition with high mortality, particularly in patients requiring mechanical ventilation due to decreased consciousness or respiratory failure. Initial neurological severity, comorbidities, and complications during hospitalization may influence patient outcomes. This study aimed to analyze factors associated with mortality in hemorrhagic stroke pa…
Background: Vascular Cognitive Impairment (VCI) represents a leading cause of post-stroke cognitive impairment in Asia, including Indonesia, with substantial implications for quality of life and economic burden. Current management strategies emphasize early detection through the identification of specific biomarkers as predictive factors. The LDL/ApoB ratio is considered a more accurate surroga…
Background: Stroke is a catastrophic disease with a significant economic burden, particularly for neurointervention procedures such as mechanical thrombectomy and coiling. A disparity exists between standard costs and actual billing charges for these procedures at Dr. Mohammad Hoesin Hospital Palembang. This study aimed to analyze the factors influencing hospitalization costs of stroke patients…
Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, predominantly presenting with sensory symptoms such as numbness and tingling. Conservative therapy with oral mecobalamin is widely used; however, the onset of improvement is often slow. Perineural injection of mecobalamin may provide a faster local effect, but clinical evidence remains limited. This study aimed t…
ABSTRACT THE CORRELATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND COGNITIVE FUNCTION IN ELDERLY PATIENTS AT THE GERIATRIC OUTPATIENT CLINIC OF RSMH PALEMBANG Devin Fidela, Yuniza, Nur Riviati, Iche A. Liberty Department of Internal Medicine, Faculty of Medicine, Sriwijaya University Dr. Mohammad Hoesin Hospital Palembang Background: Cognitive impairment represents a major public health c…
Background: Aging is often accompanied by cognitive decline, where Mild Cognitive Impairment (MCI) serves as a transitional phase at risk of developing into dementia. The pathophysiology of this condition is closely related to neurobiological mechanisms, including low levels of Brain-Derived Neurotrophic Factor (BDNF) and the high prevalence of Vitamin D insufficiency in the elderly population.…
Pendahuluan: Proses penuaan menyebabkan penurunan massa otot, kekuatan otot, dan performa fisik (sarkopenia), yang dipengaruhi oleh inflamasi kronik tingkat rendah dengan peningkatan kadar interleukin-6 (IL-6). Extra Virgin Olive Oil (EVOO) mengandung polifenol seperti hydroxytyrosol dan oleuropein yang bersifat antioksidan dan antiinflamasi, berpotensi memperbaiki fungsi otot pada lansia. Tuju…
Latar Belakang: Gangguan tidur pada remaja secara global cukup besar, sekitar 25-30%. Sementara itu gangguan pada proses tidur dapat menimbulkan masalah serius pada kesehatan fisik dan perilaku pada remaja. Tujuan: Mengidentifikasi faktor-faktor yang memengaruhi gangguan tidur pada remaja SMP di Palembang. Metode: Penelitian ini merupakan observasional analitik dengan desain potong lintang pada…
Penelitian ini dilakukan di Sungai Napalan, Desa Umpam, Kecamatan Lengkiti, Kabupaten Ogan Komering Ulu, Sumatera Selatan, yang bertujuan untuk menganalisis karakteristik mikrofosil foraminifera pada batugamping Formasi Baturaja bagian bawah, tengah, dan atas. Metode penelitian meliputi studi pendahuluan, observasi lapangan, analisis laboratorium, serta interpretasi data di studio. Dari 15 loka…
ABSTRAK Latar Belakang: Dokter gigi muda rentan mengalami gangguan kesehatan mental, seperti depresi, kecemasan, dan stres akibat tingginya tekanan akademik maupun klinis yang mereka hadapi. Tujuan: Menganalisis kesehatan mental dokter gigi muda di Rumah Sakit Khusus Gigi dan Mulut Provinsi Sumatera Selatan serta faktor-faktor yang memengaruhinya. Metode: Penelitian ini menggunakan desain mixed…
Nekrosis pulpa pada gigi permanen muda menyebabkan terhentinya perkembangan akar sehingga gigi rentan mengalami fraktur. Perawatan yang bertujuan meregenerasi kompleks dentin-pulpa pada gigi permanen muda yang mengalami nekrosis adalah prosedur endodontik regeneratif. Kitosan telah digunakan sebagai scaffold pada prosedur tersebut, akan tetapi potensi regeneratifnya belum cukup optimal. Fucoida…
Background: Orthodontic treatment using clear aligners or fixed appliances often causes pain in patients. This pain may affect comfort and compliance during orthodontic therapy. Objective: This study aims to determine whether there is a difference in pain intensity among malocclusion patients undergoing treatment with clear aligners compared to fixed orthodontic appliances. Methods: This resear…
Latar Belakang: Vitamin D berperan penting sebagai pelindung dalam patogenesis sepsis dengan cara meredam inflamasi neutrofil dan menjaga fungsi limfosit. Rendahnya kadar vitamin D berkontribusi langsung pada buruknya profil hematologi (seperti tingginya RNL) dan peningkatan risiko gagal organ pada pasien sepsis. Penelitian ini bertujuan untuk mengetahui korelasi antara kadar vitamin D dengan r…
Introduction: Laryngoscopy and endotracheal intubation may provoke sympathetic activation, resulting in increased blood pressure and heart rate, particularly in hypertensive patients. Opioids such as fentanyl and sufentanil are commonly used to attenuate this hemodynamic response. However, comparative evidence regarding their effects in hypertensive patients remains limited. Methods: This doubl…
Background. Anaplastic Large Cell Lymphoma (ALCL) is a mature T-cell lymphoma characterized by strong CD30 expression and is classified into ALK-positive and ALK-negative subtypes. Although both subtypes share similar histopathological features, differences in ALK expression are associated with distinct biological behavior, treatment response, and prognosis. International studies have reported …
Pendahuluan: Pasien penyakit ginjal kronik (PGK) yang menjalani hemodialisis kronik memiliki risiko tinggi mengalami infeksi laten tuberkulosis (ILTB) akibat kondisi imunokompromais. Defisiensi vitamin D diketahui berperan dalam penurunan respons imun terhadap Mycobacterium tuberculosis. Namun, hubungan antara kadar vitamin D 25(OH) dengan kejadian ILTB pada populasi hemodialisis di Indonesia m…
Blind children are a group of children who have limited vision or are totally blind. Blind children have obstacles in communication, limited learning media, and lack of teaching resources. A survey from the World Health Organization (WHO) shows that blind children under 15 years of age have worse dental and oral health than normal children. This is because blind children have difficulty detecti…