Optimization of the extraction process and testing of the antioxidant activity of Spirulina platensis microalgae extract is important for the development of natural microalgae-based antioxidant sources. Optimization was performed using multilevel factorial design 23 with 24 runs in Design Expert® 13 using three factors, namely solvent type (ethanol, acetone), temperature (25°C, 40°C), and ex…
Pelawan leaves (Tristaniopsis merguensis Griff.) are a plant that contain important secondary metabolites such as flavonoids, tannins, saponins, and phenolic compounds, which have potential roles in regulating lipid metabolism. This study aimed to evaluate the effect and effective dose of the ethanolic extract of pelawan leaves in reducing total cholesterol, Low Density Lipoprotein (LDL), and t…
Breadfruit bark (Artocarpus altilis) is a medicinal plant containing important secondary metabolites such as flavonoids, phenolics, saponins, and triterpenoids. These compounds are thought to play a role in protecting the gastric mucosa. This study aims to evaluate the antiulcer activity of ethanol extract of breadfruit bark through biochemical parameters, macroscopic, and microscopic analysis …
Drug control in hospitals is one of the important aspects of a pharmacy installation that can be analyzed from several indicators, including damaged drugs, expired drugs, and dead stock drugs. This study aims to determine the percentage value, compliance with ideal targets, and contributing factors of damaged drugs, expired drugs, and dead stock drugs using descriptive analysis at RSI Siti Khad…
Layered Double Hydroxide (LDH) is a layered material with a large surface area and good anion-exchange capacity, but its stability remains limited. To enhance its performance, LDH was modified with Muntingia calabura (MC) extract, which is rich in flavonoids and phenolics with strong antioxidant activity (IC₅₀ < 50 μg/mL). CaAl, CaCr, and CaFe LDH–MC composites were synthesized via the c…
Latar Belakang: Penggunaan obat antijamur pada anak baik topikal maupun sistemik cenderung meningkat seiring bertambahnya kasus infeksi jamur, terutama pada pasien dengan kondisi immunocompromised. Penggunaan antijamur yang tidak rasional dapat meningkatkan efek samping, resistensi, dan biaya perawatan. Data mengenai pola penggunaan antijamur pada populasi anak di Indonesia masih terbatas sehin…
Acute Respiratory Infection (ARI) is one of the most common diseases encountered among adult patients in healthcare facilities. This study aims to evaluate drug prescribing patterns and analyze their compliance with the Ministry of Health of the Republic of Indonesia's therapy guidelines for adult ARI patients at the Sukarami Public Health Center (Puskesmas) in Palembang. This study employed a …
Ethanol extract of breadfruit (Artocarpus altilis) stem bark is known to contain flavonoid compounds suspected to have potential as an antidepressant agent. This study was conducted to determine the effect and optimal concentration of the ethanol extract of breandruit stem bark for depression treatment. The test animals were divided into six groups: normal group (Na-CMC), negative group (Na-CMC…
This study aimed to determine the chemical composition and organoleptic characteristics of lozenges made from the extract of the water lettuce plant (Pistia stratiotes) through experimental laboratory methods. The experimental design used in this study was a Randomized Block Design (RBD) with 4 formulations differing in the concentration of water lettuce extract (30%, 20%, 10%, and 0%). Each fo…
Latar belakang: Aggregatibacter actinomycetemcomitans adalah bakteri gram negatif yang paling sering ditemukan pada periodontitis. Daun sirih merah sebagai bahan alami dilaporkan memiliki kandungan senyawa berupa flavonoid, alkaloid, tanin, saponin dan minyak atsiri yang terbukti memiliki efek antibakteri. Tujuan: Mengetahui ada atau tidaknya aktivitas antibakteri ekstrak daun sirih merah (Pipe…
Kidney stone disease (antinefrolithiasis) of calcium stone type is one of the health problems among Indonesian people. The use of diuretic drugs as a treatment for kidney stones can be replaced with natural ingredients to reduce the risk of side effects. Kersen leaves (Muntingia calabura L.) contain a lot of flavanes, flavones, flavanones, flavonols, and chalcones which are included in the flav…
Background: Drug allergy is a hypersensitivity reaction to medications involving immunological mechanisms that can cause clinical manifestations ranging from mild to severe, such as rash, urticaria, and anaphylaxis. Children are a vulnerable group due to their immature immune systems and limited alternative treatment options. This study aimed to determine the distribution of drug allergy incide…
Background: Wound healing is a complex biological process that progresses through the phases of inflammation, proliferation, and remodeling. Cung kediro (Solanum lycopersicum var. cerasiforme) contains lycopene, β–carotene, vitamin C, and flavonoids, which act as potent antioxidants and have the potential to accelerate epithelialization, angiogenesis, and keratinization. This study aimed to …
Introduction: Oxidative stress is an imbalance between free radicals and endogenous antioxidants that plays a role in the pathogenesis of various degenerative diseases. Natural antioxidants from plants, particularly those containing phenolic compounds and flavonoids, have become potential alternatives for the prevention of oxidative stress. Kersen mistletoe leaves contain various secondary meta…
Thrombosis is a leading global cause of cardiovascular diseases. While anticoagulants, antiplatelet agents, and thrombolytic therapies are the standard clinical treatments, iron oxide nanoparticles offer an alternative approach due to their ability to accumulate at sites of inflammation, such as thrombi and atherosclerotic plaques. These nanoparticles can act as photothermal agents, absorbing l…
Thrombosis is a condition that occurs due to an imbalance in the hemostasis system characterized by the formation of a blood clot (thrombus) in the blood vessel wall so that it can cause ischemic stroke disease. The anti-thrombotic drugs commonly used are thrombolytics. These drugs contain fibrinolytic enzymes such as protease enzymes. Pineapple (Ananas comosus (L.) Merr) is known to have an an…
Kegiatan penelitian yang dilakukan di Sungai Saka Formasi Gumai Daerah Negeri Sindang dan sekitarnya, Kecamatan Sosoh Buay Rayap, Kabupaten Ogan Komering Ulu, Provinsi Sumatera Selatan. Lokasi penelitian terbagi menjadi delapan lokasi dengan litologi batulempung karbonat dan batupasir karbonat. Penelitian ini dilakukan untuk mengidentifikasi lingkungan batimetri dan iklim purba melalui analisi…
Barringtonia acutangula or indian oak is a type of tree that are found in many swamps and river banks in Sumatera Selatan region. Determination of total phenolic content, total flavonoid content, antioxidant activity and toxicity of indian oak (Barringtonia acutangula) leaves extract was carried out. Extraction process was carried out by using increasing polarity maceration with n-hexane, ethyl…
Background: Gout is a chronic condition caused by the accumulation of monosodium urate (MSU) crystals due to hyperuricemia, often associated with a diet high in purines, obesity, and other metabolic disorders. Allopurinol is the first-line drug used to lower serum uric acid levels in gout patients. Ensuring the correct dosage of allopurinol is essential to enhance therapeutic effectiveness and …
Pengobatan yang baik berpengaruh pada tingkat pengetahuan, kepatuhan minum obat penurun kadar kolesterol dan kualitas hidup pasien. Tujuan penelitian ini adalah menganalisis hubungan antara tingkat kepatuhan minum obat dengan kualitas hidup pasien hiperkolesterolemia di Rumah Sakit Islam Siti Khadijah Palembang. Desain penelitian dilakukan secara observasional analitik dengan pendekatan cross-s…
Introduction: Myocardial infarction (MI) is a leading cause of global mortality with reperfusion therapy as its the gold standard. However, the following myocardial ischemia-reperfusion injury (MIRI) still lacks effective pharmacologic treatment. Mapping protein interaction networks may help identify herbal-based therapeutic targets related to mitochondria which holds central role in energy met…
This study aims to analyze and assess the compliance of the implementation of the internal control system for drug inventory at the Pharmacy Installation of the Health Office of Ogan Komering Ilir District (IFK OKI). This research employs a qualitative method with a case study approach. The analysis refers to the five components of COSO (Committee of Sponsoring Organizations of the Treadway Com…
Apitherapy adalah pengobatan dengan menggunakan produk lebah madu. Penelitian ini menggunakan propolis sebagai salah satu produk lebah madu yang bertujuan untuk memperoleh data mengenai perbedaan sensasi nyeri dan perubahan ukuran lesi sebelum dan sesudah dilakukan terapi selama 4 hari. Penelitian dilakukan pada masyarakat Kelurahan Rejosari Kecamatan Pangkal Balam Kota Pangkalpinang yang mende…
Penelitian ini beijudul hubungan antara pemanfaatan pengobatan alternatif dan perilaku kesehatan pada masyarakat perkotaan (studi Kelurahan Lebung Gajah Kecamatan Sako Kota Palembang), permasalahan yang akan dibahas adalah (1) bagaimana pemanfaatan pengobatan alternatif pada masyarakat Lebung Gajah? (2) bagaimana perilaku kesehatan pada masyarakat Lebung Gajah Palembang? (3) bagaimana hubungan …
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