ANALISIS HUBUNGAN KEPATUHAN PENGGUNAAN OBAT TERHADAP KUALITAS HIDUP PASIEN GA…

Hemodialysis is the primary treatment for patients with Chronic Kidney Failure (CKD). CKD Patients experience disruptions in fluid balance, electrolyte levels, acid-base balance, hormone production, and the secretion of toxic metabolic waste. This study aims to analyze the relationship between adherence to medication use and the quality of life of CKD patients with hemodialysis therapy at RSI S…

ANALISIS HUBUNGAN PENGGUNAAN OBAT PENURUN KADAR KOLESTEROL TERHADAP KUALITAS …

Pengobatan yang baik berpengaruh pada tingkat pengetahuan, kepatuhan minum obat penurun kadar kolesterol dan kualitas hidup pasien. Tujuan penelitian ini adalah menganalisis hubungan antara tingkat kepatuhan minum obat dengan kualitas hidup pasien hiperkolesterolemia di Rumah Sakit Islam Siti Khadijah Palembang. Desain penelitian dilakukan secara observasional analitik dengan pendekatan cross-s…

EFEK PREVENTIF FRAKSI ETIL ASETAT DAUN MELINJO (Gnetum gnemon L.) SEBAGAI HEP…

Melinjo leaves (Gnetum gnemon L.) is a plan that is often used as a medicinal ingredient because it has a high content of secondary metabolites. Secondary metabolites that are thought to act as hepatoprotectors are flavonoid. This study aims to determine the decrease in SGPT and SGOT levels of various doses, determine ED50 (Effective Dose 50) and determine the effect on the macroscopic and hist…

STANDARISASI DAN UJI TOKSISITAS AKUT EKSTRAK ETANOL RIMPANG TEMU MANGGA (Curc…

Temu mango rhizome (Curcuma amada Roxb.) is one of the plants that has anti-inflammatory and antidiabetic activities. The safety of using temu mango rhizome as a natural medicinal preparation must be supported by scientific research on toxicity testing. This study aims to evaluate the characteristics of acute toxicity of ethanol extract of temu mango rhizome to female Wistar rats using the Acut…

UJI HEPATOPROTEKTOR FRAKSI ETIL ASETAT DAUN MELINJO (Gnetum gnemon L.) DAN GA…

Melinjo leaves (Gnetum gnemon L.) have benefits in the field of traditional medicine. Melinjo leaves (Gnetum gnemon L.) contain secondary metabolite compounds such as flavonoids, saponins, tannins, phenolics, and saponins. This study aims to determine the hepatoprotector activity of ethyl acetate fraction of melinjo leaves (Gnetum gnemon L.) and hepatic histopathological picture of male white r…

STANDARDISASI DAN UJI TOKSISITAS AKUT EKSTRAK ETANOL RIMPANG TEMU IRENG (Curc…

Temu ireng (Curcuma aeruginosa Roxb.) is one of the medicinal plants that has been reported to have antioxidant, antibacterial, anti-inflammatory, and hepatoprotector activities, but this plant has not been widely studied regarding its toxicity. This study conducted an acute toxicity test of ethanol extract of temu ireng rhizome against female Wistar strain rats using the Acute Toxic Class meth…

OPTIMASI DAN KARAKTERISASI DISPERSI PADAT OFLOKSASIN DENGAN VARIASI JUMLAH OF…

Ofloksasin termasuk ke dalam biopharmaceutical classification system (BCS) kelas II dengan kelarutan rendah, yang mengakibatkan bioavailabilitas obat menjadi terbatas. Penelitian ini bertujuan untuk meningkatkan kelarutan ofloksasin dengan memformulasikannya dalam sistem dispersi padat dengan natrium alginat dan kitosan yang digunakan sebagai matriks polimer. Pengembangan formula optimum disper…

UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL DAUN SUNGKAI (PERONEMA CANESCENS JA…

The leaves of Sungkai (Peronema canescens Jack) contain secondary metabolites, flavonoids, which have the potential as antidepressant activity. This study aims to determine the effect of ethanol extract of Sungkai leaves on antidepressant activity and its optimal dose. In this study, six groups were divided: the normal group (NaCMC 0,5% without acute stress induction), the negative group (NaCMC…

UJI AKTIVITAS ANTIOKSIDAN DAUN DAN BUAH TANAMAN BELIMBING WULUH (Averrhoa bli…

Free radicals are unstable molecules that can cause oxidative stress, which contributes to various degenerative diseases such as cancer, diabetes, and cardiovascular disease. Antioxidants play an important role in neutralizing free radicals by donating electrons so as to prevent cell damage. This study aims to determine the antioxidant activity and the correlation between total phenolic and fla…

FORMULASI DAN UJI ANTIBAKTERI LOTION EKSTRAK ETANOL AKAR BAJAKAH KUNING (Cosc…

Plants that have the potential as antibacterials to overcome bacteria that cause body odor (Staphylococcus epidermidis) are ethanol extracts of yellow bajakah roots which contain citral. This study aims to make lotions with various concentrations of ethanol extract of yellow bajakah root (0%, 2%, 4%, and 6%) as antibacterial against Staphylococcus epidermidis. The lotion evaluation test include…

ANALISIS RASIONALITAS TERAPI STROKE ISKEMIK DI RSUD SITI FATIMAH PROVINSI SUM…

Stroke iskemik terjadi akibat penyumbatan arteri serebral yang menghambat aliran darah ke otak, meningkatkan risiko kecacatan dan kematian. Penerapan terapi yang rasional berperan penting dalam efektivitas pengobatan dan pencegahan komplikasi. Penelitian ini bertujuan untuk menganalisis rasionalitas terapi stroke iskemik di RSUD Siti Fatimah Provinsi Sumatera Selatan. Desain penelitian yang dig…

EVALUASI PENGGUNAAN OBAT PADA PASIEN STROKE HEMORAGIK DI RSUD SITI FATIMAH PR…

Hemorrhagic stroke occurs due to bleeding or rupture of blood vessels in the brain that disrupt blood circulation. Hemorrhagic stroke occurs around 10%-20% of all types of stroke with mortality rates reaching 25% to 48%, indicating that hemorrhagic stroke has a high mortality. Rational drug administration in hemorrhagic stroke patients can affect the success of therapy. This study aims to evalu…

NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING DALAM MEMPREDIKSI AGEN SKIN WHITEN…

Skin whitening telah menjadi tren global dan banyak digunakan dalam standar kecantikan di berbagai budaya, tetapi produk ini sering menimbulkan efek samping seperti masalah dermatologis dan toksisitas. Upaya dalam mengurangi risiko ini digunakan altenatif bahan alam daun kemang (Mangifera caesia Jack.) yang lebih aman. Senyawa bioaktifnya dapat menghambat aktivitas tirosinase dan mengatur pembe…

NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING EKSTRAK JARAS GAMBIR (UNCARIA GAMB…

Edition

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ISBN/ISSN

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Collation

xxiv, 176 hlm.; ilus.; tab.; 29 cm.

Series Title

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Call Number

T1690782025

STUDI DISPERSI PADAT CEFIXIME DENGAN KOMBINASI KITOSAN DAN VARIASI NATRIUM AL…

Cefixime is a third-generation cephalosporin antibiotic known for its low solubility and permeability. Various technologies have been developed to address this issue, one of which is solid dispersion technology. In this study, chitosan and sodium alginate were used as carrier matrices to produce cefixime solid dispersions. The aim of the study was to evaluate the effect of chitosan and sodium a…

UJI AKTIVITAS NANOEMULSI CITRONELLA OIL DAN CREMOPHOR RH-40 PEMBAWA ASAM USNA…

Usnic acid is a compound with antibacterial, anti-inflammatory properties, and potential in accelerating burn wound healing. Usnic acid has good bioavailability and low solubility in water so it needs to be formulated in a nanoemulsion system with a combination of citronella oil as the oil phase and cremophor RH-40 as a surfactant. This study aims to determine the effect of variations in the co…

UJI AKTIVITAS NANOEMULSI MINYAK CENGKEH DAN CREMOPHOR RH-40 PEMBAWA ASAM USNA…

Lichen is one of the organisms known for its diverse secondary metabolites, one of which is usnic acid. Usnic acid is known to have anti-inflammatory and antibacterial activities to accelerate burn wound healing. This study aims to determine the concentration of clove oil and Cremophor RH-40 from various concentrations to obtain the optimum usnic acid nanoemulsion formula and test its activity …

UJI AKTIVITAS NANOEMULSI MINYAK PEPPERMINT DAN CREMOPHOR RH-40 PEMBAWA ASAM U…

Lichen has a secondary metabolite of usnic acid with antibacterial, antioxidant and anti-inflamatory pharmacological activities, however this compound is classified in Biopharmaceutics Classification System (BCS) class II with low solubility but high permeability so that it becomes an obstacle in topical formulation. This research aims to determine the optimum formula for usnic acid nanoemulsio…

UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL HERBA SIRIH CINA (Peperomia pelluci…

Ethanol extract of Chinese Betel Herb (Peperomia Pellucida (L.) Kunth) is known to contain secondary metabolites, including flavonoid compounds that are thought to have potential antidepressant activity. This study aims to determine the effect of ethanol extract of Chinese betel herb as an antidepressant and determine the best concentration of ethanol extract of Chinese betel herb. Parameters o…

FORMULASI DAN OPTIMASI DISPERSI PADAT OFLOKSASIN DENGAN VARIASI JUMLAH NATRIU…

Ofloxacine is a fluoroquinolone antibiotic that is classified under Biopharmaceutics Classification System (BCS) Class II, characterized by low water solubility and high permeability. This investigation aimed to enhance its solubility by utilizing a combination of sodium alginate and chitosan as carrier polymers in a solid dispersion system. The development of the optimal formulation for ofloxa…

UJI AKTIVITAS PENYEMBUHAN LUKA BAKAR DAN LUKA SAYAT DARI EKSTRAK ETANOL DAUN …

Leucas lavandulaefolia is traditional medicinal plant used to treat inflammation the finger joints and skin diseases. The aims of This study to were evaluated efficacy of Leucas lavanduleafolia leaf extract in healing burn and incision wounds. The extraction was carried out using maceration method ethanol solvent. The research used were 60 male Wistar rats, divided into six treatment groups (fi…

FORMULASI DAN AKTIVITAS ORALLY DISSOLVING FILM EKSTRAK BUNGA KECOMBRANG (Etli…

Kecombrang (Etlingera elatior) belongs to the zingiberaceae family and the rhizome of the combrang is widely used by the community as an antioxidant. Orally dissolving film preparations can neutralize the sour taste of kecombrang flowers. The results of the total flavonoid content contained 7.700%. The FII formula was determined to be the best formula for evaluating the uniformity of levels and…

UJI SINERGISME ANTIOKSIDAN KOMBINASI DAUN PEPAYA (Carica papaya), DAUN MELINJ…

Excessive free radical production can lead to oxidative stress that damages DNA, proteins and lipids, triggering serious neurodegenerative and autoimmune diseases. Oxidative damage caused by free radicals can be prevented by the activity of antioxidant compounds. Based on previous research, papaya leaves, melinjo leaves, and pelawan leaves as natural antioxidants contain flavonoids and phenolic…

UJI EFEK TERATOGENIK EKSTRAK ETANOL DAUN JENGKOL (ARCHIDENDRON JIRINGA BENTH)…

Jengkol leaves (Archidendron jiringa Benth) contain active compounds such as flavonoids, saponins, steroids and tannins. the use of herbal medicines during pregnancy must be considered carefully, because drugs can cross the placenta and so can cause teratogenic effects on the fetus. Teratogenic toxicity research of ethanol extract of jengkol leaves (Archidendron jiringa Benth) has been conducte…

UJI ANALGETIKA DAN ANTIINFLAMASI EKSTRAK DAN FRAKSI DAUN PELAWAN (TRISTANIOSI…

The ethanol extract of Pelawan leaves (Tristaniopsis merguensis Griff.) contains flavonoids, steroids, phenolics, and terpenoids, which have the potential to act as analgesics and anti-inflammatory agents due to their ability to inhibit prostaglandin formation, the main mediator of pain and inflammation. This study aimed to evaluate the characteristics of the extract as well as the analgesic an…

AKTIVITAS ANTIOKSIDAN FRAKSI DAUN PEPAYA (Carica papaya L.), DAUN PELAWAN (Tr…

The use of antioxidants can prevent oxidative stress conditions, which cause tissue damage, due to too many free radicals in the body. The body produces antioxidant compounds such as SOD (Superoxide Dismutase), Gpx (Glutathione peroxidase), and catalase to protect the endothelium of blood vessels from free radical attacks, which reduce oxidative stress. This study aims to evaluate the antioxida…

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK DAN KOMBINASI EMPAT TUMBUHAN OBAT ANTIHIPER…

The human body that is exposed to excess free radicals in a prolonged period can cause oxidative stress and various diseases so antioxidant compounds are needed to counteract free radicals. This study was conducted with the aim of determining the strongest antioxidant activity of ciplukan leaves, guava leaves, katuk leaves and cat whisker leaves that have been used empirically by the people of …

OPTIMASI DAN KARAKTERISASI HAIR SERUM EKSTRAK KULIT BAWANG MERAH (ALLIUM CEPA…

The red onion (Allium cepa L.) have a skin that contained active compounds such as flavonoids, steroids, and phenolics that have the potential as antioxidants, one of which can be used as a hair growth stimulant. This study aimed to optimize the use of gelling agents in hair serum formulations of red onion peel extract (Allium cepa L.) as a hair growth stimulant. The formula optimization was de…

ANALISIS HUBUNGAN KEPATUHAN PENGGUNAAN OBAT TERHADAP KUALITAS HIDUP PASIEN BE…

Benign Prostatic Hyperplasia (BPH) is a benign prostate enlargement that is common in elderly men. Drug therapy is the main choice treatment of BPH, but patients are susceptible to non-compliance due to long-term treatment or side effects of drugs. Non-compliance with drug use can affect the patient's quality of life. The purpose of this study was to analyze the relationship between drug compli…

OPTIMASI TRANSETOSOM EKSTRAK KULIT BUAH DELIMA (PUNICA GRANATUM L.) MENGGUNAK…

Pomegranate (Punica granatum L.) peel has been proven to contain secondary metabolites, one of which is the phenolic group in the form of ellagic acid which has potential ability as a treatment for hyperpigmentation. The deformability and elasticity of transethosomes can penetrate the stratum corneum and increase the transfer of active substances in skin permeability. This study aims to determi…