Penelitian aktivitas antidiabetes ekstrak dan fraksi buah karamunting (Rhodomyrtus tomentosa (Aiton) Hassk) terhadap tikus putih jantan galur wistar terinduksi streptozotosin bertujuan mengetahuipengaruhpemberianekstraketanoldan fraksi etil asetat buah karamuntingterhadappenurunankadarglukosadarahtikusdiabetes mellitus tipe-2 dan mengetahuidosisefektifdarivariasiekstraketanol dan fraksi etil as…
Hyperlipidemia is characterized by increased normal levels of plasma lipids such as cholesterol, triglycerides, cholesterol esters, phospholipids, and sometimes plasma lipoproteins, including very low-density lipoproteins (VLDL) and low-density lipoproteins (LDL), along with decreased high-density lipoproteins (HDL). This study used an in silico approach to predict the molecular potential of be…
Long-term exposure to excess free radicals in the body can cause oxidative stress and various diseases, so antioxidant compounds are needed to neutralize free radicals. This research was conducted to determine the strongest antioxidant activity of avocado leaves, water guava leaves and cherry leaves which have been used empirically by the Ogan Ilir community. The extract with the strongest anti…
Ibuprofen Is Classified As A Bcs Class Ii Biopharmaceutical. This Means That Researchers Use Solid Dispersion To Improve Its Solubility And Dissolution Rate, As It Has Poor Oral Solubility And Bioavailability. This Study Used A Combination Of Chitosan And Sodium Alginate To Form Solid Dispersion With Co-Grinding Technique, Which Is Easy To Do And Environmentally Friendly. In The Preparation Of …
Hyperlipidemia is a disorder of the fat metabolism system which causes an increase in total cholesterol, LDL, triglyceride levels and a decrease in blood HDL. Catechin is the main compound from gambier leaves, including flavonoid compounds which can reduce hyperlipidemia. The aim of this research was to determine the effect of administering self-nano emulsion from gambier leaf extract on lipid …
Cikori root flour (Cichorium intybus L.) is a functional food containing inulin and is useful as a prebiotic in stimulating the growth of Bifidobacterium longum (B. longum). Prebiotic cikori root flour is made into an orally dissolving film (ODF) with the advantage of fast onset without interfering with the release of active ingredients with a pleasant taste. Research was conducted to see the p…
Asam usnat mempunyai kelarutan yang rendah dalam air, sehingga menyebabkan asam usnat agak sulit diformulasi. Salah satu cara untuk meningkatkan kelarutan asam usnat adalah dengan menggunakan sistem dispersi padat. Sistem dispersi padat orally dissolving film dipilih karena ODF mampu meningkatkan bioavailabilitas sistemik diperoleh dengan cara melewati first pass effect. Orally dissolving film …
Mahogany leaves contain flavonoid, phenolic, triterpenoid, steroid, tannin and saponin compounds as antioxidants. This study aims to determine the characteristics, phytochemical screening, the effect of giving ethanol extracts and fractions of mahogany leaves on antioxidant activity with parameters of MDA levels, catalase enzyme activity, macroscopic and histopathological images of rat liver in…
Erythromycin is a topical antibiotic with anti-inflammatory and immunomodulatory activities used for the therapy of mild to moderate inflammatory acne. However, conventional topical erythromycin formulations are still ineffective as they struggle to penetrate deeper into the sebaceous areas located in the dermal layer of the skin. Therefore, it is necessary to develop a topical formulation inco…
The kandis tamarind plant is a plant that contains secondary metabolites such as flavonoids, phenolics, steroids, triterpenoids, saponins and tannins that have potential as antioxidants.The purpose of the study was to determine the characteristics and screening of kandis tamarind leaves, the effect of giving ethanol extracts and fractions of kandis tamarind leaves on MDA levels, catalase enzyme…
Breadfruit leaves (Artocarpus altilis (Parkinson) Fosberg) contain the main flavonoid compound in the form of quercetin which has potential as an antiosteoarthritis. Nanoemulsion preparation is carried out to increase drug stability and penetration. This research aims to determine the optimum concentration of Cremophor RH 40 and Ethanol 96% using the factorial 22. The optimum formula is determi…
Diabetes mellitus (DM) can cause cognitive disorders and even Alzheimer's disorders. Catechins in gambier have pharmacological effects as antioxidants and can be used as therapy to improve cognitive function and prevent Alzheimer's disease. The research aims to determine the characteristics of gambier extract and SNE as active anti-diabetic ingredients to prevent Alzheimer's disease and to dete…
Cassava leaves (Manihot Esculenta Crantz.) is proven to contain secondary metabolites, including flavonoids such as rutin, which demonstrated antibacterial capabilities. The deformability and elasticity of transethosomes penetrated the stratum corneum and increased the transfer of active substances in skin permeability. This research aimed to determine the optimum transethosome formula from var…
Erythromycin is a drug classified into Biopharmaceutical Classification System (BCS) class II which has low solubility in water so that it can reduce the speed of drug penetration into skin. One of the efforts to increase the penetration of Erythromycin is to formulate erythromycin into a nanoemulsion delivery system. The nanoemulsion was prepared by the PIT (Phase Transition Temperature) metho…
The utilization of sweet orange peel is still minimal as it is often overlooked after fruit processing for consumption, despite being rich in bioactive compounds, including flavonoids, especially for topical preparations. Previous research has mainly focused on conventional formulations with limitations in skin penetration. The Nanostructured Lipid Carrier (NLC) delivery system can enhance perc…
Excessive free radicals in the body can cause oxidative stress conditions which result in tissue damage. This condition can be prevented by consuming antioxidants. Cherry leaves (Muntigia calabura L.) often used as a medicinal plant and are believed to have antioxidant properties. Based on previous research, methanol extract of cherry leaves has strong antioxidant activity, while the ethyl acet…
Kersen leaves (Muntingia calabura L.) have been proven to have antioxidant properties, both in the form of crude extracts and fractions. The ethyl acetate fraction of kersen leaves separated by vacuum liquid column chromatography has strong antioxidant activity (IC50 43,40 µg/mL). This research is a continuation of the previous research by further separating the fraction of vacuum liquid colum…
Plants that contain high levels of flavonoid and phenol compounds have the potential to act as antioxidants and anti-inflammatories. One of them is the breadfruit plant (Artocarpus altilis). This study aims to determine the antioxidant and anti-inflammatory activity of breadfruit leaf fractions. The research began with extraction by maceration using solvents with varying polarities (n-hexane, e…
Breadfruit leaves (Artocarpus altilis) contain flavonoids and quercetin which are thought to have potential as antidepressants. This study aims to determine the effect and know the best concentration of ethanol extract of breadfruit leaves as an antidepressant. Parameters observed include immobility time, number of line crossings, length of time mice fall, amount of sucrose consumption, and cha…
Jengkol (Archidendron jiringa) is one of the medicinal plants that can be used as traditional medicine. The ethanol extract content of jengkol leaves is reported to have many pharmacological activities such as anti-inflammatory, anti-hyperuricemia, anti-hyperlipidemia and immunostimulant. However, the level of safety of using this plant is not yet known. This study aims to determine the nature …
Coronary Heart Disease (CHD) is a condition plaque forms in the arteries of the heart which can cause a heart attack. This buildup of plaque in the coronary arteries is called atherosclerosis. This study aims to determine patient demographics and the relationship between the level of compliance and the quality of life of CHD patients at RS Islam Khadijah Palembang. The analytical observational …
Puskesmas merupakan fasilitas kesehatan yang menjadi tujuan pertama pasien. Oleh karena itu, diperlukan ketersediaan perbekalan farmasi yang memadai. Pasien yang datang ke puskesmas kadang mengalami keluhan obat kosong. Hal ini dapat terjadi karena kurangnya kesesuaian perencanaan dan pengadaan obat yang dapat menyebabkan terapi pasien tidak maksimal. Penelitian ini bertujuan untuk menganalisis…
Skizofrenia merupakan gangguan jiwa yang mengganggu pemikiran dan persepsi. Terapi Skizofrenia memerlukan kepatuhan yang baik untuk mencapai keberhasilan terapi dan mengurangi resiko kekambuahan pasien. Prevalensi skizofrenia di Indonesia mencapai 6,7 per 1.000 rumah tangga dan jenis terbanyak diduduki oleh Skizofrenia Paranoid. Salah satu faktor yang dapat memengaruhi kepatuhan mi-num obat ada…
Excessive sun exposure caused skin redness, inflammation, and even skin cancer. One effective way to protect the skin from the sun is by using sunscreen. Nasi-nasi leaves (Syzygium zeylanicum (L.) DC) had the potential to serve as a natural sunscreen due to their phenolic compounds, which could absorb harmful ultraviolet (UV) rays. This study aimed to explore the potential of sunscreen gel extr…
Melinjo leaves (Gnetum gnemon L) is one plant that has many properties, one of which is as a diuretic. Active compounds such as alkaloids, flavonoids, steroids, and tannins can be found in melinjo. Antinephrolithiasis testing of ethanol fraction of melinjo leaves was carried out in vivo with the aim of determining the effect on ureal levels, creatinine and calcium, crystalluria and urine pH, as…