OPTIMASI ORALLY DISSOLVING FILM (ODF) ASAM USNAT DENGAN POLIMER HYDROXYPROPYL…

Asam usnat mempunyai kelarutan yang rendah dalam air, sehingga menyebabkan asam usnat agak sulit diformulasi. Salah satu cara untuk meningkatkan kelarutan asam usnat adalah dengan menggunakan sistem dispersi padat. Sistem dispersi padat orally dissolving film dipilih karena ODF mampu meningkatkan bioavailabilitas sistemik diperoleh dengan cara melewati first pass effect. Orally dissolving film …

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAN FRAKSI DAUN MAHONI (Swietenia ma…

Mahogany leaves contain flavonoid, phenolic, triterpenoid, steroid, tannin and saponin compounds as antioxidants. This study aims to determine the characteristics, phytochemical screening, the effect of giving ethanol extracts and fractions of mahogany leaves on antioxidant activity with parameters of MDA levels, catalase enzyme activity, macroscopic and histopathological images of rat liver in…

OPTIMASI DAN KARAKTERISASI NANOEMULSI ERITROMISIN DENGAN VARIASI KONSENTRASI …

Erythromycin is a topical antibiotic with anti-inflammatory and immunomodulatory activities used for the therapy of mild to moderate inflammatory acne. However, conventional topical erythromycin formulations are still ineffective as they struggle to penetrate deeper into the sebaceous areas located in the dermal layer of the skin. Therefore, it is necessary to develop a topical formulation inco…

POTENSI EKSTRAK ETANOL DAN FRAKSI DAUN ASAM KANDIS (GARCINIA PARVIFOLIA (MIQ.…

The kandis tamarind plant is a plant that contains secondary metabolites such as flavonoids, phenolics, steroids, triterpenoids, saponins and tannins that have potential as antioxidants.The purpose of the study was to determine the characteristics and screening of kandis tamarind leaves, the effect of giving ethanol extracts and fractions of kandis tamarind leaves on MDA levels, catalase enzyme…

OPTIMASI KONSENTRASI CREMOPHOR RH 40 DAN ETANOL 96% DALAM FORMULASI SEDIAAN N…

Breadfruit leaves (Artocarpus altilis (Parkinson) Fosberg) contain the main flavonoid compound in the form of quercetin which has potential as an antiosteoarthritis. Nanoemulsion preparation is carried out to increase drug stability and penetration. This research aims to determine the optimum concentration of Cremophor RH 40 and Ethanol 96% using the factorial 22. The optimum formula is determi…

EFEK PEMBERIAN SELF-NANO EMULSION (UNCARIA GAMBIR ROXB.) TERHADAP PROFIL NEUR…

Diabetes mellitus (DM) can cause cognitive disorders and even Alzheimer's disorders. Catechins in gambier have pharmacological effects as antioxidants and can be used as therapy to improve cognitive function and prevent Alzheimer's disease. The research aims to determine the characteristics of gambier extract and SNE as active anti-diabetic ingredients to prevent Alzheimer's disease and to dete…

OPTIMASI DAN UJI AKTIVITAS ANTIBAKTERI TRANSETOSOM FRAKSI ETIL ASETAT DAUN SI…

Cassava leaves (Manihot Esculenta Crantz.) is proven to contain secondary metabolites, including flavonoids such as rutin, which demonstrated antibacterial capabilities. The deformability and elasticity of transethosomes penetrated the stratum corneum and increased the transfer of active substances in skin permeability. This research aimed to determine the optimum transethosome formula from var…

OPTIMASI DAN KARAKTERISASI NANOEMULSI ERITROMISIN DENGAN VARIASI KONSENTRASI …

Erythromycin is a drug classified into Biopharmaceutical Classification System (BCS) class II which has low solubility in water so that it can reduce the speed of drug penetration into skin. One of the efforts to increase the penetration of Erythromycin is to formulate erythromycin into a nanoemulsion delivery system. The nanoemulsion was prepared by the PIT (Phase Transition Temperature) metho…

OPTIMASI FORMULA NANOSTRUCTURED LIPID CARRIER EKSTRAK KULIT JERUK MANIS (Citr…

The utilization of sweet orange peel is still minimal as it is often overlooked after fruit processing for consumption, despite being rich in bioactive compounds, including flavonoids, especially for topical preparations. Previous research has mainly focused on conventional formulations with limitations in skin penetration. The Nanostructured Lipid Carrier (NLC) delivery system can enhance perc…

AKTIVITAS ANTIOKSIDAN SENYAWA METABOLIT SEKUNDER DARI FRAKSI ETIL ASETAT DAUN…

Excessive free radicals in the body can cause oxidative stress conditions which result in tissue damage. This condition can be prevented by consuming antioxidants. Cherry leaves (Muntigia calabura L.) often used as a medicinal plant and are believed to have antioxidant properties. Based on previous research, methanol extract of cherry leaves has strong antioxidant activity, while the ethyl acet…

PEMISAHAN FRAKSI KOLOM DARI FRAKSI ETIL ASETAT DAUN KERSEN (MUNTINGIA CALABUR…

Kersen leaves (Muntingia calabura L.) have been proven to have antioxidant properties, both in the form of crude extracts and fractions. The ethyl acetate fraction of kersen leaves separated by vacuum liquid column chromatography has strong antioxidant activity (IC50 43,40 µg/mL). This research is a continuation of the previous research by further separating the fraction of vacuum liquid colum…

EVALUASI AKTIVITAS ANTIOKSIDAN DAN ANTIINFLAMASI FRAKSI DAUN SUKUN (Artocarpu…

Plants that contain high levels of flavonoid and phenol compounds have the potential to act as antioxidants and anti-inflammatories. One of them is the breadfruit plant (Artocarpus altilis). This study aims to determine the antioxidant and anti-inflammatory activity of breadfruit leaf fractions. The research began with extraction by maceration using solvents with varying polarities (n-hexane, e…

UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis) TER…

Breadfruit leaves (Artocarpus altilis) contain flavonoids and quercetin which are thought to have potential as antidepressants. This study aims to determine the effect and know the best concentration of ethanol extract of breadfruit leaves as an antidepressant. Parameters observed include immobility time, number of line crossings, length of time mice fall, amount of sucrose consumption, and cha…

UJI TOKSISITAS SUBKRONIS EKSTRAK ETANOL DAUN JENGKOL (Archidendron jiringa) P…

Jengkol (Archidendron jiringa) is one of the medicinal plants that can be used as traditional medicine. The ethanol extract content of jengkol leaves is reported to have many pharmacological activities such as anti-inflammatory, anti-hyperuricemia, anti-hyperlipidemia and immunostimulant. However, the level of safety of using this plant is not yet known. This study aims to determine the nature …

ANALISIS TINGKAT KEPATUHAN PENGGUNAAN OBAT TERHADAP KUALITAS HIDUP PASIEN PEN…

Coronary Heart Disease (CHD) is a condition plaque forms in the arteries of the heart which can cause a heart attack. This buildup of plaque in the coronary arteries is called atherosclerosis. This study aims to determine patient demographics and the relationship between the level of compliance and the quality of life of CHD patients at RS Islam Khadijah Palembang. The analytical observational …

ANALISIS PENGADAAN DAN PERENCANAAN OBAT DI PUSKESMAS KOTA PALEMBANG BERDASARK…

Puskesmas merupakan fasilitas kesehatan yang menjadi tujuan pertama pasien. Oleh karena itu, diperlukan ketersediaan perbekalan farmasi yang memadai. Pasien yang datang ke puskesmas kadang mengalami keluhan obat kosong. Hal ini dapat terjadi karena kurangnya kesesuaian perencanaan dan pengadaan obat yang dapat menyebabkan terapi pasien tidak maksimal. Penelitian ini bertujuan untuk menganalisis…

KORELASI PERAN DUKUNGAN KELUARGA TERHADAP KEPATUHAN MINUM OBAT PASIEN SKIZOFR…

Skizofrenia merupakan gangguan jiwa yang mengganggu pemikiran dan persepsi. Terapi Skizofrenia memerlukan kepatuhan yang baik untuk mencapai keberhasilan terapi dan mengurangi resiko kekambuahan pasien. Prevalensi skizofrenia di Indonesia mencapai 6,7 per 1.000 rumah tangga dan jenis terbanyak diduduki oleh Skizofrenia Paranoid. Salah satu faktor yang dapat memengaruhi kepatuhan mi-num obat ada…

FORMULASI GEL TABIR SURYA EKSTRAK DAN FRAKSI DAUN NASI NASI (Syzygium zeylani…

Excessive sun exposure caused skin redness, inflammation, and even skin cancer. One effective way to protect the skin from the sun is by using sunscreen. Nasi-nasi leaves (Syzygium zeylanicum (L.) DC) had the potential to serve as a natural sunscreen due to their phenolic compounds, which could absorb harmful ultraviolet (UV) rays. This study aimed to explore the potential of sunscreen gel extr…

Farmasi Fisik: DASAR-DASAR KIMIA FISIK DALAM ILMU FARMASETIK 2, EDISI KETIGA

Edition

2

ISBN/ISSN

979-456-117-7

Collation

724-1362 hlm. : ilus. ; 23 cm.

Series Title

-

Call Number

615.1 Mar f

UJI ANTINEFROLITHIASIS FRAKSI ETANOL DAUN MELINJO (Gnetum gnemon L.) TERHADAP…

Melinjo leaves (Gnetum gnemon L) is one plant that has many properties, one of which is as a diuretic. Active compounds such as alkaloids, flavonoids, steroids, and tannins can be found in melinjo. Antinephrolithiasis testing of ethanol fraction of melinjo leaves was carried out in vivo with the aim of determining the effect on ureal levels, creatinine and calcium, crystalluria and urine pH, as…

UJI EFEK ANTIDIABETES FRAKSI N-HEKSAN KULIT BUAH PISANG (Musa balbisiana C.) …

Kulit buah pisang kepok (Musa balbisian C.) diketahui mengandung metabolit sekunder flavonoid yang memiliki efek antidiabetes. Tujuan dilakukan penelitan ini untuk mengetahui efektivitas penurunan kadar glukosa darah fraksi n-heksan kulit buah pisang . Penelitian ini dibagi menjadi 6 kelompok yaitu kelompok normal (suspense Na-CMC 0,5%), kontrol positif (metformin 9mg/kgBB), kontrol negatif (su…

UJI KADAR FLAVONOID TOTAL DAN AKTIVITAS ANTIOKSDIAN SECARA IN VITRO PADA FRAK…

Free radical can trigger chain reactions that cause damage to cell-forming particles that can have an impact on health. One of the plants that has the potential as a source of antioxidants is purple sweet potato leaves (Ipomoea batatas L. Poir) which contains a secondary metalbolite component with antioxidant effectiveness relatively higher than tocopherol. This study aims to determine the Anti…

PREPARASI DAN UJI AKTIVITAS ANTIDIABETES NANOSUSPENSI EKSTRAK DAUN MELINJO (G…

Melinjo leaves has pharmacological activity as an antidiabetic because it contains flavonoid compounds which can inhibit glucose absorption, stimulate insulin secretion or act as insulin and can regulate the work of enzymes that play a role in carbohydrate metabolism. The effectiveness and bioavailability of extracts tend to be low so that the formula in the form of nanosuspension is an option …

PREPARASI DAN UJI AKTIVITAS ANTIDIABETES NANOSUSPENSI EKSTRAK DAUN MELINJO (G…

Melinjo leaves are known to have pharmacological activity as antidiabetics because they contain flavonoid compounds that can reduce blood glucose levels with their ability to act as antioxidants that protect β-cell damage as insulin producers and can increase insulin sensitivity. The effectiveness, bioavailability, and solubility of extracts tend to be low, so the formula in the form of nanosu…

UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL DAUN CEMPEDAK (Artocarpus champeden…

Cempedak (Artocarpus champeden) leaves contain flavonoids that are efficacious as antioxidants which are thought to have potential as antidepressant activity. This study aims to determine the effect of cempedak leaf ethanol extract as an antidepressant and find out the best concentration of cempedak leaf ethanol extract as an antidepressant. Parameters observed included length of fall, immobili…

UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN KENCANA UNGU (Ruellia tuberosa L.) TE…

Daun kencana ungu (Ruellia tuberosa L.) mengandung senyawa metabolit sekunder seperti flavonoid, alkaloid, tannin, saponin dan steroid yang memiliki efek terapi sebagai antidiabetes dan diuretik. Senyawa yang terkandung bermanfaat sebagai obat perlu diketahui keamanannya yang didukung dengan pengujian toksisitas. Tujuan penelitian ini untuk mengetahui hasil ekstraksi dan skrining fitokimia, dos…

AKTIVITAS ANTIBAKTERI NANOEMULSI DAUN SAMBILOTO DENGAN KOMBINASI TWEEN 80 DAN…

Bitter leaf extract (Andrographis paniculate (Burm.f) Wall. Ex Ness) contains secondary metabolites andrographolide and quercetin which have potential antibacterial activity. This research aims to determine the nanoemulsion formulation with a combination of Tween 80 and Ethanol 96% concentration on the activity of Propionibacterium acnes and the stability of ICH Q1A (R2). Data analysis in this …

UJI AKTIVITAS NANOFIBER KOMBINASI EKSTRAK DAUN SIRIH (Piper betle) DAN DAUN B…

Open wounds are very susceptible to infection, can become ulcers and even chronic if they are not treated and cared for properly. Nanofiber as a modern wound dressing can deliver medicinal ingredients for caring wound. Betel leaves (Piper betle) and Binahong leaves (Anredera cordifolia) contain flavonoids, saponins, tannins which can accelerate the wound healing process. The aim of this study i…

ANALISIS HUBUNGAN TINGKAT KEPATUHAN MINUM OBAT ANTITUBERKULOSIS TERHADAP KUAL…

Pulmonary tuberculosis treatment for a long time at least 6 months with side effects making it a challenge for patients to complete treatment. Cases of low adherence to taking medication are still found in pulmonary TB patients. This study aim to analyze the relationship between medication adherence and the quality of life of pulmonary TB patients. Analytical observational research design with …

STUDI SISTEM DISPERSI PADAT ASAM MEFENAMAT DENGAN KOMBINASI KITOSAN DAN NA-AL…

Mefenamic acid is a drug included in the biopharmaceutical classification system (BCS) class II so it is difficult to dissolve water which is overcome by making it into a solid dispersion. The combination of chitosan and sodium alginate is used as a carrier substance in solid dispersion. This study aims to determine the effect of chitosan and sodium alginate as a carrier on the dissolution rate…