ANALISIS RASIONALITAS TERAPI STROKE ISKEMIK DI RSUD SITI FATIMAH PROVINSI SUM…

Stroke iskemik terjadi akibat penyumbatan arteri serebral yang menghambat aliran darah ke otak, meningkatkan risiko kecacatan dan kematian. Penerapan terapi yang rasional berperan penting dalam efektivitas pengobatan dan pencegahan komplikasi. Penelitian ini bertujuan untuk menganalisis rasionalitas terapi stroke iskemik di RSUD Siti Fatimah Provinsi Sumatera Selatan. Desain penelitian yang dig…

EVALUASI PENGGUNAAN OBAT PADA PASIEN STROKE HEMORAGIK DI RSUD SITI FATIMAH PR…

Hemorrhagic stroke occurs due to bleeding or rupture of blood vessels in the brain that disrupt blood circulation. Hemorrhagic stroke occurs around 10%-20% of all types of stroke with mortality rates reaching 25% to 48%, indicating that hemorrhagic stroke has a high mortality. Rational drug administration in hemorrhagic stroke patients can affect the success of therapy. This study aims to evalu…

NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING DALAM MEMPREDIKSI AGEN SKIN WHITEN…

Skin whitening telah menjadi tren global dan banyak digunakan dalam standar kecantikan di berbagai budaya, tetapi produk ini sering menimbulkan efek samping seperti masalah dermatologis dan toksisitas. Upaya dalam mengurangi risiko ini digunakan altenatif bahan alam daun kemang (Mangifera caesia Jack.) yang lebih aman. Senyawa bioaktifnya dapat menghambat aktivitas tirosinase dan mengatur pembe…

NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING EKSTRAK JARAS GAMBIR (UNCARIA GAMB…

Edition

-

ISBN/ISSN

-

Collation

xxiv, 176 hlm.; ilus.; tab.; 29 cm.

Series Title

-

Call Number

T1690782025

STUDI DISPERSI PADAT CEFIXIME DENGAN KOMBINASI KITOSAN DAN VARIASI NATRIUM AL…

Cefixime is a third-generation cephalosporin antibiotic known for its low solubility and permeability. Various technologies have been developed to address this issue, one of which is solid dispersion technology. In this study, chitosan and sodium alginate were used as carrier matrices to produce cefixime solid dispersions. The aim of the study was to evaluate the effect of chitosan and sodium a…

UJI AKTIVITAS NANOEMULSI CITRONELLA OIL DAN CREMOPHOR RH-40 PEMBAWA ASAM USNA…

Usnic acid is a compound with antibacterial, anti-inflammatory properties, and potential in accelerating burn wound healing. Usnic acid has good bioavailability and low solubility in water so it needs to be formulated in a nanoemulsion system with a combination of citronella oil as the oil phase and cremophor RH-40 as a surfactant. This study aims to determine the effect of variations in the co…

UJI AKTIVITAS NANOEMULSI MINYAK CENGKEH DAN CREMOPHOR RH-40 PEMBAWA ASAM USNA…

Lichen is one of the organisms known for its diverse secondary metabolites, one of which is usnic acid. Usnic acid is known to have anti-inflammatory and antibacterial activities to accelerate burn wound healing. This study aims to determine the concentration of clove oil and Cremophor RH-40 from various concentrations to obtain the optimum usnic acid nanoemulsion formula and test its activity …

UJI AKTIVITAS NANOEMULSI MINYAK PEPPERMINT DAN CREMOPHOR RH-40 PEMBAWA ASAM U…

Lichen has a secondary metabolite of usnic acid with antibacterial, antioxidant and anti-inflamatory pharmacological activities, however this compound is classified in Biopharmaceutics Classification System (BCS) class II with low solubility but high permeability so that it becomes an obstacle in topical formulation. This research aims to determine the optimum formula for usnic acid nanoemulsio…

UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL HERBA SIRIH CINA (Peperomia pelluci…

Ethanol extract of Chinese Betel Herb (Peperomia Pellucida (L.) Kunth) is known to contain secondary metabolites, including flavonoid compounds that are thought to have potential antidepressant activity. This study aims to determine the effect of ethanol extract of Chinese betel herb as an antidepressant and determine the best concentration of ethanol extract of Chinese betel herb. Parameters o…

FORMULASI DAN OPTIMASI DISPERSI PADAT OFLOKSASIN DENGAN VARIASI JUMLAH NATRIU…

Ofloxacine is a fluoroquinolone antibiotic that is classified under Biopharmaceutics Classification System (BCS) Class II, characterized by low water solubility and high permeability. This investigation aimed to enhance its solubility by utilizing a combination of sodium alginate and chitosan as carrier polymers in a solid dispersion system. The development of the optimal formulation for ofloxa…

UJI AKTIVITAS PENYEMBUHAN LUKA BAKAR DAN LUKA SAYAT DARI EKSTRAK ETANOL DAUN …

Leucas lavandulaefolia is traditional medicinal plant used to treat inflammation the finger joints and skin diseases. The aims of This study to were evaluated efficacy of Leucas lavanduleafolia leaf extract in healing burn and incision wounds. The extraction was carried out using maceration method ethanol solvent. The research used were 60 male Wistar rats, divided into six treatment groups (fi…

FORMULASI DAN AKTIVITAS ORALLY DISSOLVING FILM EKSTRAK BUNGA KECOMBRANG (Etli…

Kecombrang (Etlingera elatior) belongs to the zingiberaceae family and the rhizome of the combrang is widely used by the community as an antioxidant. Orally dissolving film preparations can neutralize the sour taste of kecombrang flowers. The results of the total flavonoid content contained 7.700%. The FII formula was determined to be the best formula for evaluating the uniformity of levels and…

UJI SINERGISME ANTIOKSIDAN KOMBINASI DAUN PEPAYA (Carica papaya), DAUN MELINJ…

Excessive free radical production can lead to oxidative stress that damages DNA, proteins and lipids, triggering serious neurodegenerative and autoimmune diseases. Oxidative damage caused by free radicals can be prevented by the activity of antioxidant compounds. Based on previous research, papaya leaves, melinjo leaves, and pelawan leaves as natural antioxidants contain flavonoids and phenolic…

UJI EFEK TERATOGENIK EKSTRAK ETANOL DAUN JENGKOL (ARCHIDENDRON JIRINGA BENTH)…

Jengkol leaves (Archidendron jiringa Benth) contain active compounds such as flavonoids, saponins, steroids and tannins. the use of herbal medicines during pregnancy must be considered carefully, because drugs can cross the placenta and so can cause teratogenic effects on the fetus. Teratogenic toxicity research of ethanol extract of jengkol leaves (Archidendron jiringa Benth) has been conducte…

UJI ANALGETIKA DAN ANTIINFLAMASI EKSTRAK DAN FRAKSI DAUN PELAWAN (TRISTANIOSI…

The ethanol extract of Pelawan leaves (Tristaniopsis merguensis Griff.) contains flavonoids, steroids, phenolics, and terpenoids, which have the potential to act as analgesics and anti-inflammatory agents due to their ability to inhibit prostaglandin formation, the main mediator of pain and inflammation. This study aimed to evaluate the characteristics of the extract as well as the analgesic an…

AKTIVITAS ANTIOKSIDAN FRAKSI DAUN PEPAYA (Carica papaya L.), DAUN PELAWAN (Tr…

The use of antioxidants can prevent oxidative stress conditions, which cause tissue damage, due to too many free radicals in the body. The body produces antioxidant compounds such as SOD (Superoxide Dismutase), Gpx (Glutathione peroxidase), and catalase to protect the endothelium of blood vessels from free radical attacks, which reduce oxidative stress. This study aims to evaluate the antioxida…

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK DAN KOMBINASI EMPAT TUMBUHAN OBAT ANTIHIPER…

The human body that is exposed to excess free radicals in a prolonged period can cause oxidative stress and various diseases so antioxidant compounds are needed to counteract free radicals. This study was conducted with the aim of determining the strongest antioxidant activity of ciplukan leaves, guava leaves, katuk leaves and cat whisker leaves that have been used empirically by the people of …

OPTIMASI DAN KARAKTERISASI HAIR SERUM EKSTRAK KULIT BAWANG MERAH (ALLIUM CEPA…

The red onion (Allium cepa L.) have a skin that contained active compounds such as flavonoids, steroids, and phenolics that have the potential as antioxidants, one of which can be used as a hair growth stimulant. This study aimed to optimize the use of gelling agents in hair serum formulations of red onion peel extract (Allium cepa L.) as a hair growth stimulant. The formula optimization was de…

ANALISIS HUBUNGAN KEPATUHAN PENGGUNAAN OBAT TERHADAP KUALITAS HIDUP PASIEN BE…

Benign Prostatic Hyperplasia (BPH) is a benign prostate enlargement that is common in elderly men. Drug therapy is the main choice treatment of BPH, but patients are susceptible to non-compliance due to long-term treatment or side effects of drugs. Non-compliance with drug use can affect the patient's quality of life. The purpose of this study was to analyze the relationship between drug compli…

OPTIMASI TRANSETOSOM EKSTRAK KULIT BUAH DELIMA (PUNICA GRANATUM L.) MENGGUNAK…

Pomegranate (Punica granatum L.) peel has been proven to contain secondary metabolites, one of which is the phenolic group in the form of ellagic acid which has potential ability as a treatment for hyperpigmentation. The deformability and elasticity of transethosomes can penetrate the stratum corneum and increase the transfer of active substances in skin permeability. This study aims to determi…

OPTIMASI DAN KARAKTERISASI FORMULA TRANSFERSOM EKSTRAK KULIT BAWANG MERAH (AL…

Red onion skin (Allium cepa L.) has been proven to promote hair growth due to its strong antioxidant activity. Transfersomes were capable of penetrating the transfollicular pathways to enhance the antioxidant effect of quercetin compounds in red onion skin extract. This study aims to optimize the transfersome formula of red onion skin extract by varying the concentrations of phospholipon 90G an…

UJI TOKSISITAS AKUT FRAKSI ETIL ASETAT DAUN GAMAL (Gliricidia sepium) TERHADA…

Gamal leaves (Gliricidia sepium) have pharmacological activity as anthelmitic, hepatoprotector and antibacterial. The content of secondary metabolites in the ethyl acetate fraction of gamal leaves are flavonoids, tannins and saponins. The purpose of this study was to determine the effects of acute toxicity of the ethyl acetate fraction of gamal leaves with testing parameters of biochemical leve…

PREPARASI DAN UJI AKTIVITAS ANTINEFROLITIASIS NANOSUSPENSI FRAKSI ETIL ASETAT…

Kidney stones (nephrolithiasis) were a common health problem in Indonesia. The kersen leaf (Muntingia calabura L.) contained flavonoid compounds that acted as diuretics. The use of nanosuspension preparations was chosen to enhance the effectiveness and bioavailability of the fraction in delivering the active substance to the target. The aim of this study was to determine the %EE and characteriz…

PREPARASI DAN UJI ANTINEFROLITIASIS FRAKSI ETANOL DAUN KERSEN (Muntingia cala…

Daun kersen (Muntingia calabura L.) diketahui memiliki efek farmakologi sebagai antinefrolitiasis karena mengandung senyawa flavonoid yang dapat berikatan dengan kalsium pada batu ginjal dan meningkatkan ekskresi urin. Senyawa bahan alam mempunyai kelarutan dan bioavailabilitas yang rendah dalam air sehingga dapat diatasi dengan inovasi sediaan berupa nanosuspensi. Penelitian ini bertujuan untu…

PENGUJIAN EKSTRAK DAN FRAKSI DAUN GELAM (Melaleuca leucadendra L.) SEBAGAI AN…

Pain and inflammation are common health issues experienced by patients. Non-steroidal anti-inflammatory drugs (NSAIDs) are often used to treat these conditions, but they come with undesirable side effects. Traditional medicine using Gelam leaves (Melaleuca leucadendra L.) may offer a promising alternative with potential analgesic and anti-inflammatory properties. Secondary metabolites in Gelam …

UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETANOL DAUN UBI JALAR UNGU (IPOMOEA BATATAS …

This study aims to determine the antioxidant activity of purple sweet potato leaf ethanol fraction against decreased levels of malondialdehyde (MDA) blood plasma and mouse pancreas in vivo by TBARS method. The ethanol fraction of purple sweet potato leaves is obtained using a multilevel maceration method using n-hexane solvent, ethyl acetate and ethanol 96%. The test animals were grouped into 6…

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK N-HEKSANA DAUN UBI JALAR UNGU (Ipomoea bata…

The aims of this study are to determine the antioxidant activity of purple sweet potato leaves in inhibiting lipid peroxidation of blood and pancreas in rats. The solvent used is n-hexane, which is non polar solvent. The test of antioxidant activity using TBARS method by measuring the levels of malondialdehyde (MDA) plasma and pancreas induced by alloxan 150 mg/kg BW. The test animals were grou…

UJI AKTIVITAS HEPATOPROTEKTOR EKSTRAK ETANOL KULIT BUAH CEMPEDAK(ARTOCARPUS C…

Uji Aktivitas Hepatoprotektor Ekstrak Etanol Kulit Buah Cempedak (Artocarpus champeden) Terhadap Kerusakan Hati Pada Tikus Putih Jantan Galur Wistar Terinduksi CCl4 Peggy Yulianda Jurusan Farmasi FMIPA Universitas Sriwijaya Abstract Cempedak peel is one of the plants that has the potential to be a source of antioxidants as an antidote to free radicals. The skin of cempedak peel ethanol extract …

ISOLASI DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA METABOLIT SEKUNDER DARI FRAKSI …

Flacourtia rukam is a plant that has been used traditionally, one of its benefits as a treatment for diarrhea and dysentry. The aims of this study to isolated secondary metabolites from the methanol fraction of rukam leaves and their antibacterial activity test against Salmonella typhi and Shigella dysentriae. This research was started by maseration method using solvent with increasing polarity…

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN BANDOTAN (Ageratum conyzoides L…

Salmonella typhi is gram negative bacteria caused typhoid fever. Typhoid fever highest cases in development country in south asian and southeast asian included Indonesian. A.conyzoides in empiric is using as herbal plant for typhoid fever treatment in Indonesian.This experiment was conducted to evaluate antibacterial activity of ethanol extract A.conyzoides leaves on rats has been infected. Cru…