Pendahuluan: Pasien penyakit ginjal kronik (PGK) yang menjalani hemodialisis kronik memiliki risiko tinggi mengalami infeksi laten tuberkulosis (ILTB) akibat kondisi imunokompromais. Defisiensi vitamin D diketahui berperan dalam penurunan respons imun terhadap Mycobacterium tuberculosis. Namun, hubungan antara kadar vitamin D 25(OH) dengan kejadian ILTB pada populasi hemodialisis di Indonesia m…
Blind children are a group of children who have limited vision or are totally blind. Blind children have obstacles in communication, limited learning media, and lack of teaching resources. A survey from the World Health Organization (WHO) shows that blind children under 15 years of age have worse dental and oral health than normal children. This is because blind children have difficulty detecti…
Introduction: Sepsis is a leading cause of morbidity and mortality in critically ill patients. While estradiol administration shows potential as a sepsis therapy, its impact on the necroptosis process remains unclear. This study aims to investigate the effect of estradiol administration on necroptosis and inflammation in a sepsis-induced Wistar rat model. Methods: This experimental study employ…
Health is a basic need that supports people’s daily activities and productivity. Hospitals, as referral health care facilities, are required to provide high-quality services in line with the implementation of the National Health Insurance (JKN) program through BPJS Kesehatan. Various problems such as limited health personnel, service time, attitudes of medical staff, and the quality of facili…
Latar Belakang: Pasien penyakit ginjal kronik (PGK) yang menjalani hemodialisis memiliki risiko lebih tinggi mengalami infeksi laten tuberkulosis (ILTB) akibat disfungsi imun dan kondisi inflamasi kronis. High-sensitivity C-reactive protein (hsCRP) merupakan penanda inflamasi yang sering meningkat pada populasi ini, namun hubungannya dengan kejadian ILTB masih belum jelas terutama di Indonesia.…
Latar Belakang : Penuaan menyebabkan penurunan massa otot, kekuatan otot, dan performa fisik akibat proses inflamasi kronik derajat rendah yang ditandai peningkatan enzim COX-2 dan ROS. EVOO mengandung senyawa fenolik seperti oleocanthal dan hydroxytyrosol yang bersifat antioksidan dan antiinflamasi melalui inhibisi jalur NF-κB–COX-2, sehingga berpotensi menekan inflamasi dan mempertahankan …
Latar Belakang: Osteoartritis (OA) lutut merupakan salah satu penyakit sendi degeneratif yang ditandai dengan penipisan kartilago hialin dan inflamasi kronik. Vitamin D memiliki peran penting dalam metabolisme tulang, modulasi respon imun, dan aktivitas kondrosit. Penurunan kadar vitamin D serum diduga berhubungan dengan penurunan ketebalan kartilago hialin. OA menjadi masalah global karena dap…
This research aims to analyze the implementation of government economic policies regarding the South Sumatra Indonesian Young Entrepreneurs Association (HIPMI) in an effort to develop Micro, Small, and Medium Enterprises (MSMEs) in Palembang City. Utilizing the implementation model by Van Meter and Van Horn, this study evaluates six key dimensions: policy standards and objectives, resources, ch…
Background: Gastric adenocarcinoma remains a global health burden with high mortality, while effective targeted therapies are still limited. Claudin-18.2 is a transmembrane tight-junction protein selectively expressed in normal gastric mucosa and retained in gastric adenocarcinoma. Its role as a novel therapeutic target, including zolbetuximab, highlights the importance of investigating claudin…
Latar Belakang: Stomatitis Aftosa Rekuren (SAR) merupakan sariawan berulang tanpa penyakit sistemik yang dapat mengganggu kualitas hidup, terutama pada mahasiswa. Salah satu faktor predisposisinya adalah pola makan yang tidak seimbang yang dapat menyebabkan defisiensi nutrisi dan menurunkan imunitas. Tujuan: “Mengetahui hubungan antara rekurensi SAR dengan jenis, jumlah, dan frekuensi pola ma…
Klebsiella pneumoniae is a Gram-negative bacterium that can cause various infectious diseases, including pneumonia. Throughout its history, this bacterium has developed resistance to antibiotics. K. pneumoniae exhibits various resistance strategies, including enzymatic modification, gene mutations, and increased efflux pumps. The increasing prevalence of resistance each year has become a key fa…
Free radicals are molecules with unpaired electrons that can cause tissue damage through oxidative stress, accelerate aging, and trigger various diseases, including cancer. Antioxidants play an important role in warding off free radicals. Purple sweet potato leaves (Ipomoea batatas L.) are known to contain active compounds such as polyphenols, flavonoids, tannins and triterpenoids which have hi…
Background: Malocclusion is commonly encountered conditions, with the global prevalence reaching 56% and up to 80% in Indonesia. One of the most frequent types of malocclusion is dental crowding. Moderate to severe dental crowding often requires premolar extraction to provide adequate space during fixed orthodontic treatment. Premolar extraction is a widely used strategy to improve dental align…
Xerostomia was closely associated with hyposalivation, which had negative impacts on oral health and led to a decreased quality of life in patients; therefore, it was necessary to increase the salivary flow rate. Gambir contained catechins and tannins, which were reported to be able to increase salivary flow rate.Objective: To determine the effect of gargling gambir solution on salivary flow ra…
Background: Tooth extraction is the most frequently performed treatment in dentistry, with a rate reaching 7.9%. The impact of tooth extraction is alveolar bone resorption, so alternative treatments are needed that can accelerate alveolar bone regeneration with natural ingredients, namely catfish collagen. Objective: To determine the benefits and effects of administering catfish collagen on the…
ASSOCIATION BETWEEN RADIOLOGICAL EXAMINATION AND PIRANI SCORE IN PATIENTS WITH CONGENITAL TALIPES EQUINOVARUS (CTEV) WITH PONSETTI METHOD MANAGEMENT AT DR. MOHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG Abstraìct Baìckground: Clinicaìl feaìtures of deformity haìve been claìssified by Piraìni, so thaìt its severity caìn be aìssessed aìt birth aìnd the progress of treaìtment caìn be mon…
Porphyromonas gingivalis is the main anaerobic bacterium responsible for gingivitis and periodontitis. The use of natural ingredients such as pineapple (Ananas comosus) and stevia has potential as antibacterial agents capable of inhibiting and even killing Porphyromonas gingivalis, and can be developed into products in the form of jelly candy. This study aimed to determine the antibacterial act…
Background: Vulvovaginal candidiasis (VVC) is a very common mucosal infection in the vagina and vulva, mostly caused by Candida albicans. Accurate diagnosis requires supportive examinations such as direct microscopic evaluation or fungal culture; however, in practice, these ancillary tests are often omitted in women presenting with vulvovaginal symptoms due to high patient burden and the need f…
Procedural pain is a common clinical issue in neonates, particularly during venipuncture. Inadequately managed pain can trigger physiological stress, hemodynamic instability, and may negatively affect long-term neurodevelopment. Non-pharmacological analgesic strategies such as oral dextrose have become a practical option due to their simplicity, safety, and ability to reduce reliance on pharmac…
Anak dengan hemofilia memiliki risiko tinggi mengalami artropati sendi akibat perdarahan berulang. Penelitian ini bertujuan untuk mengidentifikasi faktor risiko yang berhubungan dengan artropati tahap lanjut pada pasien anak dengan hemofilia. Penelitian observasional analitik dengan desain potong lintang dilakukan di RS Mohammad Hoesin Palembang pada Januari hingga Juni 2025. Sebanyak 42 anak d…
Children with Virtual Autism (VA) are at risk of developing social, emotional, and communication disorders due to excessive exposure to digital media. This study aims to determine the prevalence and risk factors of VA in children. An observational analytic study with a cross-sectional design was conducted at RSUP Dr. Mohammad Hoesin Palembang from February 2025 to June 2025. The study involved …
Background: Vitamin D deficiency is an emergency problem in Indonesia with a prevalence rate of 33% in all children and young adults and can affect the function in the field of orthopedics and traumatology, especially in the physical performance of the musculoskeletal system even there was controversial in level of molecular theory. This study aims to determine correlation of serum vitamin D le…
SAC dan CPA merupakan prosedur ACDF yang sering dilakukan pada pasien dengan stenosis kanalis servikalis. Kedua metode prosedur pembedahan tersebut menunjukkan fusion rate yang sebanding. Penelitian ini bertujuan untuk menganalisis asosiasi antara prosedur ACDF-SAC dan ACDF-CPA dengan fusion rate pada single level degenerative subaxial cervical stensosis di Rumah Sakit Umum Dr Mohammad Hoesin P…
Background: Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in Indonesia, with the majority of patients presenting at an advanced stage. Vitamin D has been suggested to play a role in improving treatment response, but clinical evidence remains limited. This study aimed to evaluate the effectiveness of vitamin D supplementation on treatment response in NPC patients undergoi…
Latar Belakang: Karsinoma nasofaring merupakan keganasan epitel mukosa yang sering ditemukan di Asia Tenggara, termasuk Indonesia, dengan tingkat kesintasan rendah akibat sifatnya yang agresif dan penyebaran limfatik maupun hematogen yang cepat. Penanda proliferasi Ki67 berperan penting dalam menilai aktivitas pembelahan sel tumor, memprediksi prognosis, serta mengevaluasi respons terhadap kemo…
Background: High-resolution computed tomography (HRCT) imaging of the temporal bone prior to mastoidectomy is a routine examination in the field of Otorhinolaryngology–Head and Neck Surgery (ENT-HNS). HRCT findings play an important role in the medical and surgical management of patients with chronic suppurative otitis media (CSOM). In addition, HRCT can serve as the basis for planning the su…
Background: Acute diffuse otitis externa is an inflammation of the skin and subcutaneous tissue of the external auditory canal, commonly caused by bacterial infection, particularly Pseudomonas aeruginosa and Staphylococcus aureus. Treatment involves ear canal cleaning, pain control, and topical antibiotic therapy using ear tampons. Single antibiotic tampons effectively treat infection but lack …
Background: Food allergy is one of the most common health problems in children, with prevalence increasing annually. However, many parents often misinterpret their children's symptoms as food allergies, even though food may not necessarily be the cause. Given the rising incidence of food allergies and the misunderstanding among parents, this study aims to determine the prevalence of food allerg…
Introduction: Cardiovascular disease is the leading cause of morbidity and mortality in chronic haemodialysis patients. Conventional assessment of systolic function using left ventricular ejection fraction (LVEF) is often less sensitive in detecting subclinical myocardial dysfunction that impacts short-term prognosis. Left ventricular Global Longitudinal Strain (GLS) is suspected to be closely …
Background: Sarcopenia is a progressive skeletal muscle disorder characterized by a decline in muscle strength, mass, and physical performance, leading to increased fall risks and reduced quality of life in the elderly. The pathogenesis is driven by "inflammaging," particularly elevated levels of Interleukin 6 (IL-6). Given the rising geriatric population in Palembang, early detection through c…