Breast cancer is the most common type of cancer in the world. Chemotherapy can be one of the treatment options and has been proven to have a significant impact on patient survival. However, there are concerns about the side effects of chemotherapy that can affect the cognitive function of patients, known as chemotherapy-induced cognitive impairment (CICI). This study aims to determine the cogni…
Chemotherapy is the main treatment for breast cancer; however, it may cause cognitive impairment, known as chemobrain, which is characterized by a decline in memory, attention, reasoning, concentration, processing speed, executive function, and visual ability. Clinicopathological factors such as age, education, marital status, cancer stage, type and number of chemotherapy cycles are believed to…
Coronary Slow-Flow Phenomenon (CSFP) is characterized by delayed coronary blood flow without significant stenosis, with a prevalence of 1–7% and 38.3% at Dr. Mohammad Hoesin General Hospital Palembang. The condition often causes recurrent chest pain and increases cardiovascular risk. Endothelial dysfunction is suspected to play a role in its pathogenesis, while dyslipidemia may contribute thr…
Cholelithiasis is the formation of gallstones due to an imbalance between cholesterol, bile salts, and phospholipids. Factors such as age, gender, and body mass index (BMI) play important roles in this process. Older age is associated with decreased activity of the enzyme 7α-hydroxylase, which reduces bile acid production, while higher estrogen levels in females increase cholesterol secretion …
Polycystic Ovary Syndrome (PCOS) is an endocrine disorder characterized by an imbalance of LH and FSH hormones, insulin resistance, and dyslipidemia, which increase the risk of metabolic complications. Purple sweet potato (Ipomoea batatas L. Poir) is known to contain anthocyanins and flavonoids with antioxidant properties that contribute to improving lipid profiles. This study aims to evaluate …
Acute coronary syndrome (ACS) is one of the leading causes of cardiovascular morbidity and mortality worldwide, including in Indonesia. This condition occurs due to the sudden obstruction of coronary blood flow caused by rupture or erosion of atherosclerotic plaques. Platelet activation plays a role in the process of atherothrombosis and the formation of coronary thrombi. Platelet indices such …
Background: Musculoskeletal pain is one of the most common occupational health problems experienced by healthcare workers, particularly dentists. In Indonesia, the prevalence of musculoskeletal disorders among dentists reaches 58.9%, indicating that this condition is a significant issue requiring proper attention. Various risk factors contribute to this condition, including working posture, str…
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. Urinary tract infection (UTI) is one of the most common complications associated with diabetes mellitus. This study aims to determine whether there is an association between patient characteristics specifically sex, age, and body mass index (BMI), and the incidence of urinary tract infection (UTI) in patients with…
Background. DSD is a heterogeneous group of congenital conditions associated with variations in chromosomes, gonads, or anatomical sex. CAH is classified as a DSD that is usually diagnosed based on ambiguous genitalia in newborn girls or salt-wasting crises. Early diagnosis and treatment of CAH DSD patients is crucial. However, a major challenge is that research conducted primarily at the natio…
Background: Neck pain is one of the most common musculoskeletal complaints among adolescents, particularly those who spend extend periods sitting and maintaining non-ergonomic neck positions during academic activities. Neck position can be assessed using the Craniovertebral Angle (CVA), which biomechanically correlates with increased load on the cervical muscles. However, evidence regarding the…
Background: The spine is the central supporting structure of the body. Adolescent Idiopathic Scoliosis (AIS) is a three-dimensional structural deformity of the spine that occurs in adolescents 10-17 years old which is characterized by lateral curvature in the frontal plane, thoracic lordosis in the sagittal plane, and rotation of the vertebrae in the transverse plane, with a Cobb angle reaching…
Background: Anemia in pregnancy is a common maternal health problem contributing to prematurity, morbidity, and maternal–infant mortality. Low hemoglobin leads to placental hypoxia, HPA-axis activation, and increased prostaglandins that trigger early uterine contractions. This study analyzed the association between anemia and prematurity at RSUP Dr. Mohammad Hoesin Palembang. Methods: This an…
Background: The liver is susceptible to damage due to exposure to free radicals, which trigger oxidative stress. This condition increases AST and ALT enzymes, which are markers of liver injury. This study used CCl₄-induced Wistar rats as a model of liver damage. Antioxidants are needed to prevent damage, and silymarin was used as a positive control. Purple sweet potato leaf extract contains f…
Background. Endometrial carcinoma is a gynecological malignancy originating from the endometrial lining of the uterus. It ranks as the sixth most common cancer among women worldwide, and its incidence is associated with excessive estrogen exposure to the endometrium. This study aims to describe the risk profile and therapeutic modalities of patients with endometrial carcinoma treated at RSUP Dr…
Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by a wide spectrum of clinical manifestations, ranging from mild cutaneous abnormalities to severe organ dysfunction. Previous studies have shown a decrease in lymphocyte count, or lymphopenia, in SLE patients, which is often associated with disease activity. However, research on the relationship betwee…
Background: Hypospadias is the second most common congenital anomaly found in males after cryptorchidism, with urethrocutaneous fistula being the most frequent postoperative complication. The incidence rate of urethrocutaneous fistula is one of the indication of the success of hypospadias management. The age at surgery is suspected to play a role in determining the treatment outcome. However, r…
Komplikasi umum yang dapat terjadi selama kehamilan adalah hipertensi, termasuk preeklampsi, hipertensi gestasional, dan hipertensi kronis, yang mempengaruhi hingga 10% kehamilan. Hipertensi yang tidak ditangani dengan baik dapat menyebabkan berbagai masalah kesehatan serius bagi ibu dan janin, seperti penyakit arteri koroner, penyakit ginjal kronis, dan hambatan pertumbuhan janin. Komplikasi a…
Dysmenorrhea is a common complaint among young adult women that can impair quality of life and academic performance. The prevalence of dysmenorrhea in Indonesia reaches 64.25%. Calcium, as an essential micronutrient, is believed to play a role in women's reproductive health; however, calcium intake among young women in Indonesia remains below the Recommended Dietary Allowance. Previous studies …
Introduction. Low back pain (LBP) is a common musculoskeletal complaint influenced by various risk factors. Yoga, as a non-pharmacological therapy, is known to help improve LBP symptoms. This study aimed to determine the characteristics of LBP and the profile of yoga practice in community X in Palembang City. Methods. This study was a descriptive observational study with a cross-sectional appro…
Background: Tuberculous meningitis (TBM) is the most severe form of tuberculosis infection in children, often leading to neurological disability and death. Diagnosis is frequently delayed due to nonspecific symptoms and limited diagnostic resources in healthcare settings. This study aimed to describe the clinical characteristics of pediatric TBM patients at Mohammad Hoesin General Hospital, Pal…
Background: Cholestasis is a condition characterized by impaired bile formation and/or obstruction of bile flow, commonly occurring within the first three months of life. The age at presentation influences the clinical outcomes of infants with cholestasis. Infants presenting after three months of age have surpassed the ideal period for early detection and evaluation of cholestasis as recommende…
Background: Tuberculosis (TB) is an infectious disease that remains a major global health problem, including in Indonesia. One of the most common forms of extrapulmonary TB is tuberculous pleurisy, which is characterized by pleural fluid accumulation due to a hypersensitivity reaction triggered by Mycobacterium tuberculosis infection. Diagnosis is established through clinical examinations, radi…
Background: Craniomaxillofacial fractures are among the most common trauma cases found in emergency departments, often leading to functional, aesthetic, and psychological impairments. These conditions can significantly affect the patient’s quality of life even after reconstructive surgery. However, studies examining the relationship between patient characteristics and post-reconstruction qual…
Background: Osteoarthritis (OA) is one of the most common degenerative diseases of chronic musculoskeletal disorders, particularly in the elderly. The prevalence of knee osteoarthritis is higher compared to other joint OA. Clinical symptoms experienced by patients with knee OA include pain, stiffness, and limited range of motion (ROM), which lead to decreased physical function, difficulties in …
Background: Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that frequently causes nosocomial infections and exhibits strong biofilmforming ability as well as high resistance to various antibiotics, including carbapenems. The increasing incidence of MDR-P. aeruginosa highlights the need for alternative antimicrobial agents derived from natural sources. Karamunting leaves (Rhod…
Background: Hyperglycemia in type 2 DM, characterized by elevated HbA1c, can cause diabetic dyslipidemia, which increases cardiovascular risk. Various atherogenic indices are used to predict this risk. This study aims to analyze the correlation of HbA1c with atherogenic index of plasma (AIP), atherogenic coefficient (AC), and Castelli risk index (CRI) in type 2 DM patients. Methods: This observ…
Background. ST Elevation Myocardial Infarction (STEMI) is the most severe form of acute coronary syndrome caused by total occlusion of the coronary artery, leading to myocardial ischemia and necrosis. Blood pressure in the early phase of STEMI reflects the patient’s hemodynamic condition and plays an important role in determining clinical outcomes. Measuring blood pressure upon hospital admis…
Background: Endometrial carcinoma is an epithelial malignancy that occurs in the endometrium, the innermost layer of the uterine wall. Endometrioid endometrial carcinoma is the most common histopathological type of endometrial carcinoma. This type is associated with estrogen exposure without progesterone (unopposed estrogen) and risk factors such as advanced age, obesity, and nulliparity. Study…
Background: Adiposity indices are anthropometric measures used to assess the amount and distribution of body fat. Changes in fat distribution may influence the morphology of various body parts, including the auricle. The auricle exhibits variations in shape and size that may reflect changes in adipose tissue composition. This study aims to determine the relationship between adiposity indices an…
Background: Coronary Artery Disease (CAD), particularly Acute Coronary Syndrome (ACS) with ST-Elevation Myocardial Infarction (STEMI), is a leading cause of morbidity and mortality worldwide. Coronary artery occlusion in STEMI patients disrupts blood flow to the myocardium, triggering clinical symptoms such as angina, dyspnea, arrhythmias, and cardiogenic shock. This study aims to analyze the r…