Gamal leaves (Gliricidia sepium) contain several secondary metabolites, considered efficacious as hepatoprotector. This study aims to determine the activity of the ethanol extract of Gamal leaves as a hepatoprotector by measuring levels of SGPT, SGOT and ALP and liver histopathology of Wistar male white rats. Mice were divided into six groups: normal group (0.5% Na CMC suspension), positive gro…
One source of antioxidants is phycocyanin from the microalga Spirulina platensis which has pharmacological activity as a natural antioxidant. This study aims to determine the antioxidant activity of phycocyanin from Spirulina platensis microalgae in vitro using the DPPH and FRAP methods. Based on the results of this study, the antioxidant activity of the positive control of vitamin C have IC50 …
KIN THAT IS EXPOSED TO EXCESSIVE SUN EXPOSURE CAN RESULT IN SEVERAL LOSSES THAT CAN DAMAGE THE SKIN INCLUDING PREMATURE AGING, SKIN DAMAGE BY ULTRAVIOLET RADIATION, AND SUNBURN OR BURNING REACTIONS. SUNSCREEN IS NEEDED TO PROTECT THE SKIN FROM DAMAGE CAUSED BY UV RAYS. ZINC OXIDE IS A PHYSICAL SUNSCREEN AGENT THAT IS OFTEN USED AS AN ACTIVE INGREDIENT IN SUNSCREEN PREPARATIONS. AVOCADO LEAVES H…
Breadfruit leaves (Artocarpus altilis (Park.) Fosberg) are reported to contain flavonoids which have activity as photoprotective agents due to their ability to absorb UV light. This study aims to determine the effect of various extracts on the effect of the anti-erythema activity test of sunscreen gel with HPMC carrier. Sunscreen gels were made with ethyl acetate extract of breadfruit leaves us…
Daun sambiloto (Andrographis paniculata (Burm.f.) Nees) merupakan tanaman yang mengandung senyawa aktif seperti andrografolida (diterpenlactone), flavonoid, asam quinic, steroid, saponin, alkaloid dan tanin yang memiliki potensi sebagai antiinflamasi, antioksidan, antibakteri, dan mempercepat penyembuhan luka. Penelitian ini bertujuan untuk mengoptimasi Gelling Agent pada sediaan gel ekstrak sa…
Chitooligosacchride is a complex compound of the glycoprotein group which has a 1,4 glucosamine bond. Chitooligosaccharide as a natural cationic antibacterial agent is widely believed to occur because it interacts and disrupts the structure of the cell wall or cell membrane. This study aims to determine the effect of variations of chitooligosacchride as an anti-acne against Propionibacterium ac…
Asam usnat dapat ditemukan pada lumut, dan terutama melimpah seperti pada genus Alectia, Cladonia, Usnea, Lecanora, Ramalina dan Evernia. Banyak lumut dan ekstrak yang mengandung asam usnat telah digunakan untuk kosmetik dan pengobatan. Asam usnat masih terbilang jarang digunakan dalam pengobatan dikarenakan termasuk dalam BCS kelas II dan tergolong praktis tidak larut dalam air. Pembuatan Oral…
ABSTRACT Drug planning determines the type and amount of drugs aimed at implementing rational drug use and increasing the efficiency of drug use. However, patients often complain about the availability of drugs at the Health Center because of vacancies. This is due to the inaccuracy of drug planning and procurement. This study aimed to analyze drug procurement at the Palembang City Health Cente…
Daun sukun (artocarpus altilis) dilaporkan memiliki kandungan flavonoid yang memiliki aktivitas antioksidan dan antiinflamasi yang berpotensi memperbaiki fungsi ginjal. Penelitian ini bertujuan untuk mengetahui pengaruh variasi dosis terhadap efek nefroprotektif. Parameter yang diamati meliputi volume urin, pH urin, kreatinin serum, ureum serum, protein urin, klirens kreatinin, serta dilakukan …
Kenikir leaves has pharmacological activity as an antidiabetic because it contains flavonoid compounds in the form of quersetin which can become the α-glukosidase enzyme inhibitor so that excess blood glucose level can be lowered. The effectiveness and bioavailability of extracts tend to be low so that the formula in the form of nanosuspension is an option for improving the delivery system whi…
White tea has pharmacological activity as an antidiabetic because it contains polyphenol compounds in the form of epigallocatechin gallate (EGCG) which can inhibit the α-glucosidase enzyme so that blood glucose levels can be returned within normal limits. However, plant extracts have low oral bioavailability, so the formula in the form of SNEDDS (Self-Nano Emulsifying Drug Delivery Systems) is…
Soursop leaf and sapodilla leaf contain secondary metabolit is flavonoid which is antioxidant. The study aimed to the characteristic of the ethanol extract soursop leaf (Annona muricata L.) and sapodilla leaf (Manilkara zapota L.), total flavonoid contents, and antioxidant activity of combine ethanol extract soursoup leaf and sapodilla leaf using DPPH method. The treatment of antioxidant activi…
Daun beluntas (Pluchea indica L.) mengandung metabolit sekunder seperti flavonoid yang berpotensi sebagai antioksidan. Tujuan penelitian ini adalah untuk mengetahui karakterisasi, jumlah kadar flavonoid total, dan pengaruh pemberian fraksi etil asetat daun beluntas terhadap kadar MDA, aktivitas enzim katalase, gambaran makroskopik dan histopatologi hepar tikus yang diinduksi CCl4, serta mengeta…
Azitromisin mempunyai sifat sebagai antibiotik turunan makrolida, namun memiliki kelarutan yang rendah dalam air. Sehingga dikelompokkan kedalam sistem klasifikasi biofarmasetika (BCS) kelas II. Berbagai cara telah dilakukan untuk meningkatkan laju disolusi, salah satunya dengan dispersi padat. Dispersi padat adalah campuran yang terdiri dari satu atau lebih zat aktif dalam pembawa yang bersifa…
Skizofrenia merupakan salah satu ganggu jiwa berat yang ditandai dengan kesulitan pada penderita untuk membedakan antara nyata dan tidak nyata dalam kehidupan sehari-hari seperti halusinasi dan delusi. Manajemen terapi yang digunakan pada pasien skizofrenia adalah menggunakan terapi antipsikotik. Efek samping yang sering muncul akibat terapi antipsikotik adalah gejala ekstrapiramidal. Penelitia…
Gout is an arthritis disease that occurs due to increased levels of uric acid in the blood (hyperuricemia), causing the deposition of monosodium urate (MSU) crystals in the joints. Rational drug use in gout patients can affect the success of therapy. This study aims to determine the correlation between the rationality of drug use and clinical outcomes in gout patients at RSI Siti Khadijah Palem…
Microalgae Chlorella sp. contains phenolic secondary metabolites and carotenoids which have antioxidant activity. Previous studies reported that many of the chemical components of Chlorella such as phenolic compounds, β-carotene, ascorbic acid and tocopherols exhibit antioxidant properties. In this study the aim was to measure the phenolic and carotenoid content of the microalgae Chlorella sp.…
Azitromisin adalah antibiotik golongan makrolida yang termasuk ke dalam BCS (Biopharmaceutical Classification System) kelas II, yang memiliki kelarutan buruk, bioavailabilitas oral yang buruk, dan permeabilitas yang tinggi. Pembuatan dispersi padat Azitromisin dilakukan dengan menggunakan teknik kokristalisasi menggunakan metode bead milling (penggilingan) yang dilakukan dengan tujuan memperkec…
In this research, an improved bundle pricing model was established for internet financing schemes based on the utility function of perfect substitute and the utility function of function of bandwidth diminished with increasing bandwidth with the types of financing in the form of flat fees, usage based, and two-part tariffs. The modification model involves a utility function that considers the l…
Ekstrak etil asetat daun nangka (Artocarpus heterophyllus) mengandung senyawa metabolit sekunder berupa flavonoid yang memiliki aktivitas antioksidan dan antiinflamasi yang berpotensi memperbaiki fungsi ginjal. Penelitian ini bertujuan mengetahui aktivitas perbaikan fungsi ginjal dari ekstrak etil asetat daun nangka (EEADN). Uji aktivitas perbaikan ginjal dilakukan selama 28 hari menggunakan 30…
Typhoid fever is an acute systemic infectious disease caused by Salmonella typhi which is transmitted via fecal and oral routes and is treated with antibiotics. The purpose of this study was to determine patient characteristics, patterns of antibiotic use and the DDD/100 patient-days value of typhoid fever pediatric patients at Dr.H.Moh Rabain Muara Enim General Hospital. This research is a des…
This research aims to know whether factors such as intellectual capital, managerial ownership, institutional ownership, independent commissioners, and audit committees can influence company value. This research uses a quantitative approach with the research object being companies in the LQ45 Index that joined from 2018 - 2022. The data collection technique used is documentation. The data used i…
Ischemic stroke is a stroke caused by a blood clot or embolism blocking a cerebral artery. Ischemic stroke occurs in almost 70-85% of cases and is the most common type of stroke. This ischemic stroke disease can be given antiplatelet drug therapy with a mechanism of action in the form of inhibiting platelet aggregation. The use of antiplatelet drugs needs to be investigated to know whether it w…
This study aims to examine the effect of good corporate governance on firm value. The independent variable in this study is good corporate governance which is proxied using the variables of institutional ownership, managerial ownership, board of directors, independent board of commissioners, and audit committee while the dependent variable is firm value. Firm value is measured using price to bo…
Chitooligosaccaharide adalah senyawa turunan dari kitosan hasil proses deasetilasi kitin dan senyawa kompleks golongan glikoprotein yang memiliki ikatan 1,4 glukosamin mampu bersifat antimikroba. Penelitian ini bertujuan mengetahui variasi konsentrasi chitooligosaccharide sebagai antijerawat terhadap bakteri Propionibacterium acnes hasil tersebut dianalisa menggunakan Program SPSS®.Variasi kon…
Asthma is a chronic inflammatory disease of the respiratory tract that causes bronchial hyperactivity to various stimuli, both directly and indirectly. Asthma is included in te top ten causes morbidity and mortality in Indonesia. This study aims to determine the accuracy of using asthma drug in asthma patients at the Inpatient Installation of the Siti Khadijah Islamic Hospital Palembang for the…
Breadfruit leaves (Artocarpus altilis (Park.) Fosberg) contain flavonoids which have activity and have the potential to act as photoprotective agents because of their ability to absorb UV light. This study aims to determine the effect of variations in the formulation of breadfruit leaf ethyl acetate extract on the effect of activity tests as a sunscreen with Carbomer 940 and Triethanolamine as …
Exposure to direct sunlight for a long time can cause damage to the epidermal tissue of the skin which is a factor in the emergence of erythema and causes skin cancer. Sunscreen is a cosmetic product that functions to protect the skin from exposure to UV rays. Breadfruit leaves (Artocarpus altilis) are reported to contain antioxidant compounds which have the potential to be active ingredients f…
Sambiloto leaves extract (Andrographis paniculata (Burm.f.) Wall. Ex Ness) contains andrographolid and flavonoid main secondary metabolites which have potential as ultraviolet radiation protection and antioxidant activity as photoprotective agents. This research aims to determine the optimization of Tween 80 and Ethanol 96% concentrations to increase their photoprotective and stability. Optimiz…
Daun cempedak (Artocarpus champeden) mengandung metabolit sekunder berupa flavonoid yang memiliki aktivitas antioksidan dan antiinflamasi yang berpotensi dalam memperbaiki fungsi ginjal. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etil asetat daun cempedak (EEADC) terhadap volume dan pH urin, kadar kreatinin dan ureum serum, kadar protein urin, klirens kretinin dan gamb…