Background: Hydatidiform mole is part of the spectrum of gestational trophoblastic disease and may progress to gestational trophoblastic tumor (GTT). This progression is thought to be associated with dysregulation of cell proliferation, cell-cycle control, and apoptosis. Molecular biomarkers such as Vitamin D Receptor (VDR), Ki-67, p21, p27, p63, and Bcl-2 are involved in oncogenic signaling pa…
Introduction: Sepsis is a leading cause of morbidity and mortality in critically ill patients. While estradiol administration shows potential as a sepsis therapy, its impact on the necroptosis process remains unclear. This study aims to investigate the effect of estradiol administration on necroptosis and inflammation in a sepsis-induced Wistar rat model. Methods: This experimental study employ…
Total Hip Arthroplasty (THA) adalah prosedur umum untuk mengatasi kerusakan sendi pinggul yang disebabkan oleh osteoartritis. Kinerja implan sendi pinggul dalam jangka waktu lama sangat bergantung pada mekanika kontak di permukaan artikulasi antara femoral head dan acetabular cup. Penelitian ini bertujuan mengevaluasi dampak mekanika kontak pada berbagai konfigurasi bantalan CoCrMo on UHMWPE da…
Mechanism of Gut Microbiota Dysbiosis in Polycystic Ovary Syndrome Through the Assessment of Microbial Count, Zonulin, Short Chain Fatty Acids, Insulin-like Growth Factor-1, Homeostasis Model Assessment of Insulin Resistance, and Ovarian Follicle Count Background: Polycystic ovary syndrome (PCOS) with insulin resistance is a complex endocrine disorder involving multifactorial interactions betwe…
Introduction: Sepsis remains a leading cause of mortality in intensive care units. Fluid resuscitation is the cornerstone of management; however, excessive volume may exacerbate inflammation, activate necroptosis, and aggravate organ injury. This study aimed to evaluate the effect of different fluid resuscitation volumes on inflammation, necroptosis, and renal injury in a lipopolysaccharide (LP…