Ibuprofen is included in the Biopharmaceutical Classification System (BCS) Class II, namely drugs with irregular, slow and incomplete absorption properties. The combination of chitosan polymer with sodium alginate will increase the solubility of ibuprofen without causing systemic toxicity. Making a solid dispersion of ibuprofen using the co-grinding technique is carried out with the aim of redu…
Erythromycin has the properties of a macrolide derivative antibiotic, but erythromycin has the disadvantage that it is not soluble in water. One way to increase the solubility of erythromycin is through a solid dispersion system. The solid dispersion that has been made is then formulated into a gel preparation with the aim of inserting erythromycin through the skin pores. The gel base used is H…