Nekrosis pulpa pada gigi permanen muda menyebabkan terhentinya perkembangan akar sehingga gigi rentan mengalami fraktur. Perawatan yang bertujuan meregenerasi kompleks dentin-pulpa pada gigi permanen muda yang mengalami nekrosis adalah prosedur endodontik regeneratif. Kitosan telah digunakan sebagai scaffold pada prosedur tersebut, akan tetapi potensi regeneratifnya belum cukup optimal. Fucoida…
Background: Sinonasal lesions are disorders of the nasal cavity and paranasal sinuses that include both neoplastic and non-neoplastic conditions. The wide variation in lesion types and differences in characteristics by age and sex make analysis of sinonasal case patterns important to support appropriate management. This study aimed to determine the clinicohistopathological characteristics of si…
Background. Steroid-resistant nephrotic syndrome (SRNS) represents a subtype of nephrotic syndrome associated with less favorable clinical outcomes compared to its steroid-sensitive counterpart. Despite its relatively low incidence, SRNS plays a substantial role in accelerating the progression toward chronic kidney disease and, ultimately, end-stage renal failure. In the Indonesian context, esp…
Background: Maternal Separation (MS) is a condition in which the mother and offspring are separated during the early stages of life, a critical period for the formation of physiological and psychological systems. This separation may induce stress that affects the Hypothalamus–Pituitary–Adrenal (HPA) axis, increases corticosterone levels, and alters brain structures such as the amygdala and …
Background. Neurofeedback therapy is a non-pharmacological approach that trains patients to regulate their brain activity through an EEG-based feedback system. This method has been applied to support neurological recovery in conditions such as stroke, epilepsy, and sleep disorders. However, its clinical implementation in Indonesia remains limited. This study aimed to describe the characteristic…
Background. Chronic cervicitis is a condition characterized by inflammation of the cervix lasting for more than three months and is frequently found in women of reproductive age. This condition can be caused by microbial infections, trauma, or other non-infectious factors. This study aims to describe the clinical cytopathological characteristics of patients with chronic cervicitis at RSUP Dr. M…
Background. Tension-Type Headache (TTH) is one of the most common primary headaches among young adults, especially medical students who are often exposed to intense academic pressure and long hours of gadget use. Digital devices play an important role in daily learning activities, yet prolonged screen time may contribute to physical complaints, including TTH. This study aimed to explore whether…
Background: Hyperuricemia is a condition associated with increased systemic inflammatory responses, characterized by elevated levels of tumor necrosis factor alpha (TNF-α) and uric acid. Allopurinol is one of the first-line treatments for hyperuricemia. Cherry leaf (Muntingia calabura L.) is known to contain flavonoids with anti-inflammatory and antihyperuricemic activities. Methods: An in viv…
Background: Retinoblastoma is the most common intraocular malignancy in children and remains associated with high mortality in developing countries due to delayed diagnosis and limited access to care. Epidemiological data in Indonesia, especially in Palembang, are limited. This study aimed to describe the prevalence and characteristics of retinoblastoma patients at Mohammad Hoesin General Hospi…
Background: Mitral Valve Replacement surgery is the surgical replacement of the mitral valve with an artificial valve. Clinical informations regarding mitral valve replacement surgery are needed to help predict complications and mortality after surgery. This study aims to determine the profile of patients undergoing Mitral Valve Replacement surgery at Dr. Mohammad Hoesin General Hospital Palemb…
Introduction. Temporary pacemaker (TPM) is used to manage severe bradycardia, defined as a heart rate
Introduction. Anesthesiology residents work in rooms with minimal sunlight exposure, placing them at increased risk of vitamin D deficiency. Research regarding the association between duration of residency training and vitamin D levels among anesthesiology residents remains limited and has shown inconsistent findings. This study aimed to analyze the relationship between length of training and v…
Background: Management of drug-resistant tuberculosis (DR-TB) has improved with the introduction of shorter regimens following the approval of bedaquiline in 2012. Despite its benefits, bedaquiline carries a black box warning due to its potential to prolong the QT interval, raising concerns about cardiotoxicity. This study aimed to evaluate changes in QTcF, determine the prevalence of QT prolon…
Background: Semaglutide is a GLP-1 receptor agonist used as a therapy to improve glycemic control in patients with Type 2 Diabetes Mellitus. Although its use continues to increase globally, data regarding the utilization pattern of this drug in Indonesia, remains scarce. Objective: To determine the pattern of semaglutide use among T2DM patients at Siloam Sriwijaya Hospital Palembang from Januar…
Background: Acinetobacter baumannii is an opportunistic pathogen that frequently causes nosocomial infections, especially in patients treated in the intensive care unit (ICU). This bacterium is known for its resistance to many types of antibiotics and has shown a rising trend in infection rates over the past few years. Methods: This study is a retrospective descriptive research that utilizes me…
Background: Diabetic foot ulcer is a serious complication of diabetes mellitus that can lead to amputation and increase morbidity and mortality rates. PEDIS (Perfusion, Extent, Depth, Infection, Sensation) Score is a classification system developed by the International Working Group on the Diabetic Foot (IWGDF) to assess the severity of diabetic foot ulcers and predict prognosis. This study aim…
Background: Migraine is one of the primary neurological disorders characterized by throbbing headache with or without aura symptoms. Globally, migraine affects approximately 10-14% of the population with higher prevalence in women compared to men at a ratio of 18.9% versus 9.8%. Various factors are known to play a role in migraine occurrence, including age, residence, occupational status, famil…
Background. Acute Lymphoblastic Leukemia (ALL) is the most common hematologic malignancy in children, characterized by abnormal lymphoblastic. Prognosis and treatment evaluation are generally performed through invasive bone marrow examination as gold standard. Therefore, non-invasive hematological parameters are needed to predict prognosis. Platelet involved in bone marrow activation and hemost…
Background. Electrical burns are thermal injuries with high morbidity that can lead to multisystem complications, including musculoskeletal, neurological, renal, and cardiovascular disorders. Local data regarding the characteristics of electrical burn complications remain limited; therefore, this study aimed to provide a comprehensive clinical overview. Methods. This descriptive observational s…
Background: Nasopharyngeal non-Hodgkin lymphoma (NHL) is an extranodal lymphoid malignancy of the head and neck that is treated with systemic chemotherapy. Chemotherapy may be accompanied by changes in hematological parameters; therefore, monitoring of hematological profiles is required. Data regarding the hematological profile of patients with nasopharyngeal NHL in Indonesia are still limited.…
Meningioma is the most commonly diagnosed primary tumor of the central nervous system, with the majority being benign (WHO Grade I). Imaging modalities such as CT-Scan and MRI play a crucial role in the diagnosis and evaluation of meningioma. This study aims to describe the imaging features of brain scans in meningioma patients at Dr. Mohammad Hoesin General Hospital Palembang during the period…
Background: Drug allergy is a hypersensitivity reaction to medications involving immunological mechanisms that can cause clinical manifestations ranging from mild to severe, such as rash, urticaria, and anaphylaxis. Children are a vulnerable group due to their immature immune systems and limited alternative treatment options. This study aimed to determine the distribution of drug allergy incide…
Tuberculosis (TB) is an infectious disease that remains a major public health problem in Indonesia. TB transmission often occurs within households through close contact with infected individuals. This study aims to identify the risk factors associated with TB occurrence among household contacts of TB patients at Siti Fatimah Regional Hospital, South Sumatra. This research employed a descriptive…
Background: Wound healing is a complex biological process that progresses through the phases of inflammation, proliferation, and remodeling. Cung kediro (Solanum lycopersicum var. cerasiforme) contains lycopene, β–carotene, vitamin C, and flavonoids, which act as potent antioxidants and have the potential to accelerate epithelialization, angiogenesis, and keratinization. This study aimed to …
Background: Epidural hematoma (EDH) is defined as the accumulation of blood between the dura mater and the internal table due to trauma. Epidural hematoma occupies intracranial space, which can cause rapid expansion of bleeding. This causes pressure on the brain and triggers clinical manifestations such as decreased consciousness, reversible or irreversible disability, and even death. GCS is th…
Background. Systemic Lupus Erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by the production of autoantibodies and excessive immune activation, resulting in widespread organ damage. Immunosuppressive therapy constitutes a cornerstone in the management of SLE by suppressing abnormal immune responses and preventing further organ injury. The effectiveness of such ther…
Background: Menstruation is a physiological process experienced by adolescent girls as a sign of reproductive maturity. Inadequate personal hygiene practices during menstruation can increase the risk of urinary tract and reproductive tract infections. Female students living in Islamic boarding schools face unique challenges, such as limited sanitation facilities, lack of privacy, and cultural f…
Introduction: Oxidative stress is an imbalance between free radicals and endogenous antioxidants that plays a role in the pathogenesis of various degenerative diseases. Natural antioxidants from plants, particularly those containing phenolic compounds and flavonoids, have become potential alternatives for the prevention of oxidative stress. Kersen mistletoe leaves contain various secondary meta…