Melinjo leaves are known to have pharmacological effects as antidiabetics because they contain flavonoid compounds that are able to lower blood glucose levels by reducing glucose and regulating the excretory activity of enzymes seen in carbohydrate metabolism. Bioavailability, effectiveness, and low solubility of extracts in water are major problems in drug formulation. This can be overcome by …
Gnetum gnemon leaves contained flavonoids that had the potential to dissolve kidney stones by increasing urinary citrate excretion and diuresis. The low bioavailability of fractions required nanoparticle dosage forms as an option to increase the effectiveness of the delivery system. This study aimed to determine the percentage of nanosuspension entrapment efficiency used for in vivo tests and t…