Open wounds are very susceptible to infection, can become ulcers and even chronic if they are not treated and cared for properly. Nanofiber as a modern wound dressing can deliver medicinal ingredients for caring wound. Betel leaves (Piper betle) and Binahong leaves (Anredera cordifolia) contain flavonoids, saponins, tannins which can accelerate the wound healing process. The aim of this study i…