Background: Endometriosis is a chronic gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity, often associated with chronic pelvic pain and infertility. Ferritin is an iron-storage protein that also acts as an inflammatory marker. Elevated ferritin levels may reflect the inflammatory process and recurrent bleeding that occur in endometriosis. Obje…
Background: Adenomyosis is a condition in which endometrial tissue is present within the myometrium and can cause pelvic pain, abnormal bleeding, and fertility problems. The mechanism of adenomyosis development is not fully understood, but several risk factors have been associated with it. This study aimed to determine the relationship between age, age at menarche, parity, menstrual cycle lengt…
Latar belakang: Kadar Cancer Antigen-125 (CA-125) serum meningkat sesuai dengan derajat endometriosis. Pada stadium endometriosis lanjut, proliferasi sel juga akan meningkat yang ditandai dengan tingginya ekspresi protein Ki-67. Jika kemampuan proliferasi sel meningkat maka sel tersebut akan menyebabkan pertumbuhan yang tak terkendali seperti tumor. Penelitian ini bertujuan untuk mengetahui kor…
Background. Endometriosis is a condition characterized by the presence of endometrium-like tissue outside the uterine cavity, which can induce a chronic inflammatory response. The most common clinical symptom observed in patients with endometriosis is pain, often manifesting as dysmenorrhea. Dysmenorrhea refers to pain associated with menstruation. The onset of endometriosis can occur during ad…
Endometriosis is a disease characterized by the presence of endometrial tissue outside the uterine cavity that can trigger inflammation. Menstrual characteristics such as early menarche, short menstrual cycles, prolonged menstrual duration, and excessive menstrual volume may increase the likelihood of endometriosis. This study is an observational analytic study with a case control design to det…
Latar Belakang: Endometriosis merupakan penyakit ginekologis kronis dengan patogenesis multifaktorial, melibatkan faktor menstruasi retrograde, metaplasia selomik, gangguan imunitas, serta ekspresi abnormal berbagai mediator inflamasi dan enzim proteolitik. Penelitian ini bertujuan mengevaluasi korelasi antara kadar serum Matrix Metalloproteinase-9 (MMP-9) dan Cancer Antigen 125 (CA-125) terhad…
Background: Endometriosis is a chronic condition in which the implantation of functional uterine tissue outside the uterine cavity causes dysmenorrhea, dyspareunia, dyschezia, and dysuria. Establishing a diagnosis is quite difficult, using operative methods such as laparotomy and anatomical pathology. The purpose of this study is to determine the relationship between clinical symptoms and the l…
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Introduction: Endometriosis is a benign gynecologic disorder often occurring in reproductive-age women marked by the presence of endometrial glands and stromal cells outside the uterine cavity. The etiology of endometriosis remains unclear until now, but genetic factors possibly contribute in the pathogenesis of endometriosis. One of the genetic factors thought to be influencing the occurrence …
Introduction: Endometriosis, a disease defined as the growth of endometrial tissue with glands and/or stroma outside the uterine cavity, generally occurs in reproductive-age women. Although the etiology still remain unclear, heredity and genetic mutations may contribute in the occurrence of endometriosis. One of the genetic mutations, i.e. PROGINS (306-bp Alu insertion) polymorphism. This polym…