Background. Human Immunodefeciency Virus (HIV) is an RNA virus that targets the immune system, particularly CD4+ cells, rendering individuals more susceptible to opportunistic infections, including Hepatitis C Virus (HCV). HCV/HIV coinfection has become an increasingly complex public health issue, as both viruses share similar transmission routes, especially through the sharing or needles and h…
Background: Chronic hepatitis B is an infectious disease that can cause liver fibrosis. If not treated further, it will develop into cirrhosis and liver cancer. Therefore, an examination is needed to determine the severity of chronic liver disease. Various examination methods have been carried out to determine the level of liver fibrosis, but some areas have limited examination tools, especiall…
Background: Hepatic cirrhosis is a late-stage pathologic condition of liver damage. Diagnosis of fibrosis progression as early as possible is necessary to prevent disease progression to hepatic cirrhosis and to support patient prognosis. In the diagnosis of hepatic cirrhosis, the FIB-4 score is one of the non-invasive biomarkers that is easy to perform through its simple examination. Previous s…
Background: Chronic hepatitis B infection progresses through distinct phases that reflect the dynamic interplay between the hepatitis B virus (HBV) and the host immune system. Exhausted CD8+ T cells are marked by increased PD-1 expression, while soluble PD-1 (sPD-1), a soluble form of the PD-1 receptor, regulates immune responses. Both sPD-1 and CD8+ T cells play critical roles in determining i…
Chronic kidney disease (CKD) merupakan proses patofisiologis yang penyebabnya beragam, sehingga dapat mengakibatkan penurunan fungsi fisiologis ginjal secara progresif dan bersifat irreversible. CKD masih prioritas utama, pada tahun 2019 diperkirakan sekitar 1,4 juta kematian di dunia akibat CKD. Hemodialisis prinsipnya tindakan yang bersifat invasif sehingga mempunyai risiko untuk terjadinya i…
Hepatitis B adaiah proses peradangan pada hati yang disebabkan oleh infeksi virus yang dikenal sebagai virus hepatitis B yang dapat berujung pada kematian (nekrosis) pada sel hati. Infeksi hepatitis B akut merujuk kepada infeksi yang baru didapat dan biasanya gejala menghilang dalam beberapa minggu sampai bulan serta dengan menghilangnya penanda serologi hepatitis B berupa HBsAg kurang dari 6 b…
Hepatitis C merupakan salah satu penyakit hati menular dari hasil infeksi virus, yaitu virus hepatitis C. Menurut data dari organisasi kesehatan sedunia (WHO) pada tahun 2000, angka kejadian infeksi virus hepatitis C di Indonesia hampir 2,4% dari seluruh penduduk (sekitar 7 juta orang). Wabah hepatitis C yang masih belum jelas dari mana sumber infeksinya dapat menyerang semua umur dan apabila d…
Introduction: Chronic Hepatitis B is a global infectious health problem caused by the hepatitis B virus. Laboratory tests such as HBsAg and HBV DNA hold an important role in chronic hepatitis B. Besides, examination of the degree of liver fibrosis based on fibroscan is the main role in determining the diagnosis. This study aims to investigate the distribution frequency of chronic hepatitis B pa…
Hepatitis A is a health problem in the world, including Indonesia. At the end of 2019, South Sumatra Province, Ogan Ilir District, had Hepatitis A cases with 305 cases of hepatitis A. There were 262 cases of hepatitis A reported at the UPT Clinic Sriwjaya University, including students from Sriwijaya University who live in Indralaya. The purpose of this study was to determine and analyze the re…
Penelitian sirosis hepatis et causa hepatitis B bukan sebuah hal yang baru dalam dunia kedokteran saat ini. Namun, pengetahuan akan karakteristik pasien pada kasus ini di Palembang masih kurang. Tujuan dari penelitian ini adalah mengetahui karakteristik pasien sirosis hepatis et causa hepatitis B yang dirawat di Bagian Penyakit Dalam RSUP. Dr. Mohammad Hoesin Palembang pada Periode 1 Janua…