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PENGARUH PEMBERIAN ESTRADIOL TERHADAP EKSPRESI BIOMARKER NEKROPTOSIS DAN PERA…
Introduction: Sepsis is a leading cause of morbidity and mortality in critically ill patients. While estradiol administration shows potential as a sepsis therapy, its impact on the necroptosis process remains unclear. This study aims to investigate the effect of estradiol administration on necroptosis and inflammation in a sepsis-induced Wistar rat model. Methods: This experimental study employ…
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- xviii, 295 hlm.; ilus.; tab.; 29 cm.
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- T1894192025
PENGARUH EKSTRAK ETIL ASETAT DAUN UBI JALAR UNGU (Ipomoea batatas L.) TERHADA…
Free radicals are molecules with unpaired electrons that can cause tissue damage through oxidative stress, accelerate aging, and trigger various diseases, including cancer. Antioxidants play an important role in warding off free radicals. Purple sweet potato leaves (Ipomoea batatas L.) are known to contain active compounds such as polyphenols, flavonoids, tannins and triterpenoids which have hi…
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- xvii, 78 hlm.; ilus.; 29 cm
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- T1629822024
EFEKTIVITAS EKSTRAK UBI JALAR UNGU (Ipomoea batatas L.) TERHADAP PENURUNAN …
Background: Purple sweet potato (Ipomoea batatas L.) is a carbohydrate food other than rice that is rich in antioxidant and anti-inflammatory compounds. There is few scientific research on the use of purple sweet potato as an herbal therapy ingredient to treat fibrosis. The purpose of this study was to determine the efficacy of purple sweet potato extract on reducing serum creatinine levels in …
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- xx, 92 hlm.; Ilus.; 29 cm
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- T1368122023
EFEK EKSTRAK DAUN KERSEN (MUNTINGIA CALABURA L.) TERHADAP PROFIL HISTOPATOLOG…
Background: Acute gouty arthritis is an inflammation caused by MSU crystal deposition in the joint. Kersen leaves contain flavonoids that have anti-inflammatory and antioxidant activities. This study aims to determine the effect of kersen (Muntingia calabura L.) leaf extract on the histopathological profile of gout model rat joints. Methods: This research is an in vivo post-test-only control gr…
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- xxi, 118 hlm.; Ilus.; 29 cm
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- T1359692023
EFEKTIVITAS PEMBERIAN EKSTRAK BAWANG MERAH TERHADAP PENURUNAN KADAR GULA DARA…
Background: Diabetes mellitus is a chronic disease characterized by the pancreas being unable to produce insulin or when the body cannot use insulin properly. This situation causes the body to experience hyperglycemia and can result in body damage and even organ and tissue failure. The main goal of therapy for diabetes mellitus sufferers is controlling blood sugar levels. Shallots (Allium cepa …
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- xviii, 78 hlm.; Ilus.; 29 cm
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- T1374732023
PENGARUH FAKTOR PERTUMBUHAN PLATELET TERHADAP KADAR TUMOR NECROSIS FACTOR ALP…
Osteoarthritis (OA) merupakan bentuk penyakit sendi yang paling umum ditemukan di dunia dan diasosiasikan oleh usia. OA bermula saat faktor katabolik, sepeti TNF-α, yang berperan pada metabolisme kartilago mendominasi dan menekan faktor anabolik membuat degradasi kartilago terjadi. Faktor pertumbuhan yang didapat dari platelet memiliki peran krusial dalam penyembuhan jaringan dan respons imun.…
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- xvii, 122 hlm.; Ilus.; 29 cm
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- T1353332023
PENGARUH FAKTOR PERTUMBUHAN PLATELET TERHADAP KADAR ALPHA-SMA PADA TIKUS PUTI…
Osteoarthritis (OA) adalah gangguan sendi yang paling umum dan merupakan penyebab utama disabilitas dengan dampak sosial ekonomi yang besar dan terjadi akibat ketidakseimbangan mediator proinflamasi dan antiinflamasi atau aktivitas anabolik dan katabolik. Penelitian ini bertujuan untuk mengetahui pengaruh Faktor Pertumbuhan Platelet (FPP) terhadap kadar Alpha-SMA. Penelitian ini merupakan studi…
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- xvii, 109 hlm.; Ilus.; 29 cm
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- T1353302023
UJI ANTIHIPERURISEMIA EKSTRAK ETIL ASETAT BATANG KAYU KUNING (ARCANGELISIA FL…
Background: Stem of yellow wood (Arcangelisia flava) is a plant that are efficacious as an antihyperuricemic. This is because it contains secondary metabolites in the form of alkaloids, flavonoids, terpenoids, and tannins. Previous research conducted in vitro research on ethyl acetate extract from stem of the yellow wood (Arcangelisia flava) which has been proven to be antihyperuricemic. This s…
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- xviii, 98 hlm.; Ilus.; 29 cm
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- T1344392023
PENGARUH FAKTOR PERTUMBUHAN PLATELET TERHADAP KADAR INTERLEUKIN-1β (IL-1β) …
Osteoarthritis (OA) adalah penyakit degeneratif tulang rawan sendi yang diikuti oleh peradangan rongga synovial. Interleukin-1β (IL-1β) bertanggung jawab pada proses terjadi OA. Faktor pertumbuhan platelet diprediksi mampu memodulasi penyembuhan OA. Tujuan penelitian ini untuk mengetahui pengaruh pemberian FPP terhadap kadar IL-1β. Eksperimental in vivo menggunakan pendekatan post-test only …
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- xix, 148 hlm.; Ilus.; 29 cm
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- T1353492023
EVALUASI MIKROANATOMI GINJAL PEMBERIAN SELF NANO EMULSION (SNE) EKSTRAK TEH P…
White tea has pharmacological activity as an antidiabetic because it contains polyphenol compounds in the form of epigallocatechin gallate (EGCG) which can inhibit the α-glucosidase enzyme so that blood glucose levels can be returned within normal limits. However, plant extracts have low oral bioavailability, so the formula in the form of SNEDDS (Self-Nano Emulsifying Drug Delivery Systems) is…
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- x, 97 hlm.; ilus.; 29 cm
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- T930412023
UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT DAUN BELUNTAS (Pluchea indica L.…
Daun beluntas (Pluchea indica L.) mengandung metabolit sekunder seperti flavonoid yang berpotensi sebagai antioksidan. Tujuan penelitian ini adalah untuk mengetahui karakterisasi, jumlah kadar flavonoid total, dan pengaruh pemberian fraksi etil asetat daun beluntas terhadap kadar MDA, aktivitas enzim katalase, gambaran makroskopik dan histopatologi hepar tikus yang diinduksi CCl4, serta mengeta…
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- xviii, 73 hlm.; ilus.; 29 cm
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- T954322023
UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETANOL DAUN MELINJO (Gnetum gnemon L.) TERHA…
Melinjo leaves (Gnetum gnemon L.) have been widely researched in their use as an efficacious medicinal plant. Flavonoid as secondary metabolite compounds contained in melinjo leaves have the potential to be antioxidants. Antioxidant activity test on the ethanol fraction of melinjo leaves was tested with in vivo method with the aim of determining its effect on malondialdehyde (MDA) levels, catal…
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- xvii, 119 hlm.; ilus.; 29 cm
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- T1044302023
UJI EFEK GASTROPROTEKTIF EKSTRAK ETANOL RIMPANG TEMULAWAK (Curcuma Xanthorrhi…
Rimpang temulawak mengandung senyawa metabolit sekunder berupa flavonoid, steroid, triterpenoid dan tannin. Penelitian ini bertujuan untuk mengetahui efek gastroprotektif ekstrak etanol rimpang temulawak melalui parameter makroskopik lambung, volume, pH, keasaman total cairan lambung, kadar mucin, serta pengamatan mikroskopik. Tikus dibagi menjadi 6 kelompok yaitu kelompok normal, kontrol posit…
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- xviii, 110 hlm.; Ilus.; 29 cm
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- T1044892023
UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT DAUN SALAM (SYZYGIUM POLYANTHUM …
Ketidakseimbangan antara jumlah radikal bebas dan antioksidan endogen tubuh menimbulkan stress oksidatif yang dapat menyebabkan kerusakan sel. Tubuh memerlukan asupan antioksidan dari luar tubuh, baik sintetis atau alami. Salah satu sumber antioksidan alami adalah daun salam yang mengandung flavonoid yang dapat menstabilkan radikal bebas. Pengujian aktivitas antioksidan fraksi etil asetat daun …
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- xxi, 126 hlm.; Ilus.; 29 cm
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- T942452023
PENGARUH PEMBERIAN FRAKSI ETANOL DAUN UBI JALAR UNGU TERHADAP ALIRAN DAN PARA…
Purple sweet potato leaves contain alkaloids, flavonoids, quinones, steroids, monoterpenes, sesquiterpenes, polyphenolics and tannins which are anti-atherosclerotic. This study aims to determine the effect of giving the ethanol fraction of purple sweet potato leaves on rat blood flow and coagulation factors and its effect on the histopathological picture of the rat aorta induced by high-fat sup…
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- xviii, 104 hlm.; ilus.; 29 cm
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- T890992023
UJI AKTIVITAS EKSTRAK ETANOL DAUN KARDIA (Bellucia pentamera Naudin) TERHADAP…
Luka terbuka merupakan luka yang mengakibatkan kerusakan pada kulit jika diabaikan akan terjadi infeksi. Tanaman obat yang telah diteliti dan dimanfaatkan untuk penyembuhan luka terbuka salah satunya yaitu daun kardia (Bellucia pentamera Naudin). Daun kardia (Bellucia pentamera Naudin) mengandung senyawa flavonoid, saponin, tannin, fenolik, dan triterpenoid sebagai antijamur, antivirus, antibak…
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- xviii, 98 hlm.; ilus.; 29 cm
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- T887462023
EFEK PEMBERIAN SNACK BAR EKSTRAK DAUN PEGAGAN (Centella asiatica L.) KOMBINAS…
Gotu Kola (Centella asiatica L.) and gambier (Uncaria gambir Roxb.) is a plant that is believed to have many benefits. The high antioxidant content, especially flavonoids, triterpenoids, polyphenols, saponins from gotu kola and gambier leaves are believed to improve memory. This study aims to determine the levels of flavonoids, levels of proximate snack bar characteristics , and to determine th…
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- xix, 98 hlm.; ilus.; 29 cm
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- T887982023
UJI EFEK ANTIULCER EKSTRAK ETANOL RIMPANG TEMU MANGGA (Curcuma amada Roxb.) T…
Rimpang temu mangga (Curcuma amada Roxb.) mengandung metabolit sekunder seperti flavonoid, kurkuminoid dan fenolik yang berpotensi memiliki aktivitas antiulcer. Penelitian ini bertujuan untuk mengetahui efek antiulcer ekstrak etanol rimpang temu mangga (EERTM) yang diinduksi etanol absolut. Efek antiulcer ini dilihat dari parameter seperti, evaluasi lesi lambung, pengukuran volume, pH, keasaman…
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- xv, 102 hlm.; ilus.; 29 cm
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- T1044952023
PENGARUH PEMBERIAN ORALLY DISSOLVING FILM EKSTRAK DAUN SUNGKAI (Peronema cane…
Peronema canescens (sungkai leaf) contains flavonoid secondary metabolites that show activity as immunostimulants. This study aims to determine the properties of Orally Dissolving Film (ODF) of sungkai leaf extract, immunomodulatory effects, macroscopic and histopathology of rat spleen. ODF was prepared using solvent casting method. Immunity parameters observed were CD4+ T cell values using PIM…
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- xv, 132 hlm.; ilus.; 29 cm
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- T1143222023
UJI TOKSISITAS AKUT FRAKSI ETIL ASETAT BUAH LAKUM AIR (Ludwigia octovalvis (J…
Ethyl acetate fraction from lakum air (Ludwigia octovalvis (Jacq.) P.H. Raven) fruit has α-glucosidase inhibitory activity as antidiabetic. The results of phytochemical screening from ethyl acetate fraction of lakum air fruit contain flavonoids, saponins, phenolics, and tannins. Based on the useful compounds, we need to know their safety, supported by toxicity testing. In this research, an acu…
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- xvii, 88 hlm.; ilus.; 29 cm
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- T892852023
UJI AKTIVITAS ANTIDIABETES FRAKSI ETIL ASETAT BUAH LAKUM AIR (Ludwigia octova…
The research on the antidiabetic activity of the ethyl acetate fraction from lakum air (Ludwigia octovalvis (Jacq.) P.H. Raven) fruit in streptozotocin-induced male white rats of wistar strain was aimed to determining the decrease in blood glucose levels, ED50 (Effective Dose 50) and the histopathological effect on the pancreas from diabetic rats type 2 treated with the ethyl acetate fraction o…
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- xix, 103 hlm.; ilus.; 29 cm
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- T891212023
PENGARUH EKSTRAK IKAN BAUNG (Hemibagrus nemerus) TERHADAP JUMLAH NEUTROFIL PA…
Background: Wound is a disruption of the continuity of the epithelial lining of the skin or mucosa due to physical or thermal damage. One of the injuries that occur in the soft tissues of the oral cavity is the post-tooth extraction wound. Herbal ingredients that can be used for wound healing are baung fish. The content of omega-3 and albumin in baung fish can be antibacterial, anti-inflammator…
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- xv, 54 hlm.; ilus.; 29 cm
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- T890722023
PENGARUH EKSTRAK BIJI DUKU (Lansium domesticum Corr)TERHADAP JUMLAH NEUTROFIL…
Background: Extraction is a minor oral surgical procedure performed to remove a tooth or tooth root from its socket on the alveolar bone in the oral cavity. The process of tooth extraction causes hard and soft tissue damage. Currently, many studies use bio-based materials, for example those from plants. One type of plant that contains bioactive compounds that can be developed is duku seeds. Bas…
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- xiv, 73 hlm.; ilus.; 29 cm
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- T796132022
PENGARUH GELATIN KULIT IKAN PATIN (PANGASIUS SP) TERHADAP PENINGKATAN JUMLAH …
Background: Traumatic ulcer are lesions of the oral mucosa caused by thermal, mechanical and chemical. Long-term use of topical medication can lead resistance to fungal infection. Several studies have shown that patin fish skin contains glycine and glutamic acid which can increase macrophage activation and fibroblast proliferation in the wound healing process that wound healing will be accelera…
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- xviii, 55 hlm.; ilus.; 29 cm
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- T801262022
EFEK ANTIINFLAMASI GEL MINYAK IKAN PATIN (Pangasius hypophthalmus) PADA TIKUS…
Background: Inflammation is the body's initial response to tissue damage caused by trauma, exposure to toxins, or infection.One of the natural ingredients that have anti-inflammatory potential is catfish oil. The purpose of this study was to determine the anti-inflammatory activity of catfish oil gel in affecting the number of neutrophil cells in male white rats of the wistar strain induced by …
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- xiv, 50 hlm.; ilus.; 29 cm
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- T712602022
PENGARUH FRAKSI AIR DAUN KARAMUNTING (RHODOMYRTUS TOMENTOSA) TERHADAP SEKRESI…
Latar Belakang: Daun tanaman karamunting memiliki potensi sebagai alternatif terapi diabetes melitus tipe 2 karena mengandung senyawa bioaktif yang memiliki aktivitas antioksidan dan antinflamasi. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian fraksi air daun karamunting (Rhodomyrtus tomentosa) terhadap sekresi insulin pada tikus model diabetes melitus tipe 2 Metode: Penelitian in…
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- xv, 105 hlm.; ilus.; 29 cm
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- T850072022
KORELASI KONDISI FISIK DAN KIMIA AIR DENGAN JUMLAH LARVA NYAMUK PADA TEMPAT P…
Mosquitoes experience 4 life cycle stages, namely eggs, larvae, pupae, and adult mosquitoes. The physical and chemical conditions of the water were important parameters that affected the growth, survival, and adaptation of mosquito larvae. TWA Punti Kayu had a potential environment and ecosystem for the spread of mosquito-borne, vector-borne diseases. The purpose of this study was to investigat…
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- xix, 105 hlm.; ilus.; 29 cm
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- T847152022
EFEKTIVITAS EKSTRAK ETANOL KULIT KAYU MANIS (Cinnamomum burmannii) TERHADAP P…
Introduction: The use of cinnamon in daily life, either as a cooking ingredient or as herbal therapy, is unknown and there has been no previous research on the efficacy of cinnamon extract as a renoprotector. This studi aims to determine the efficacy of the ethanolic extract of cinnamon bark (Cinnamomum burmannii) whether it can act as a renoprotector in lowering urea levels in the kidney. Meth…
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- xviii, 79 hlm.; ilus.; 29 cm
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- T626432022
EFEK NEFROTOKSIK GENTAMISIN TERHADAP TIKUS WISTAR.
Gentamicin is one example of an aminoglycoside that gives its users nephrotoxic side effects. Although gentamicin has had nephrotoxic effects until now there is still little research on the effects of gentamicin on the kidneys and making gentamicin as an induction drug to make animals try models of renal fibrosis. The purpose of this study was to determine the nephrotoxic effect that leads to r…
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- xxii, 60 hlm.; ilus.; 29 cm
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- T848362022
PENGARUH FRAKSI NONPOLAR KAYU MANIS (CINNAMOMUM BURMANNII) TERHADAP KADAR KOR…
Insomnia is a sleep disorder that reduces the quality of life. Insomnia affects the HPA Axis by increasing cortisol levels. Cinnamomum burmannii is a plant that has antiinflammatory and antioxidant activity. This study aims to determine effect of nonpolar fraction of cinnamon on cortisol levels. This study was an in vivo experimental study using a post-test only design and a control group at th…
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- xviii,112 hlm.; ilus.; 29 cm
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- T844132022
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