This study aims to overcome the solubility and dissolution issues of clarithromycin through a co-grinding solid dispersion system using sodium alginate, chitosan, and variations in the ball-to-powder ratio (BPR). A 23 factorial design via Design-Expert®13 software was applied for the optimization process. The ANOVA results established sodium alginate as the most dominant factor (p < 0.0001) in…
Clarithromycin is a macrolide antibiotic classified as a biopharmaceutical classification system (BCS) class II drug with low solubility, which results in limited bioavailability. This study aimed to enhance the solubility of clarithromycin by formulating it into a solid dispersion system using sodium alginate and chitosan as polymer matrices, with the addition of an alkalizer to modify the mic…