Thrombosis is a leading global cause of cardiovascular diseases. While anticoagulants, antiplatelet agents, and thrombolytic therapies are the standard clinical treatments, iron oxide nanoparticles offer an alternative approach due to their ability to accumulate at sites of inflammation, such as thrombi and atherosclerotic plaques. These nanoparticles can act as photothermal agents, absorbing l…
Thrombosis is a condition that occurs due to an imbalance in the hemostasis system characterized by the formation of a blood clot (thrombus) in the blood vessel wall so that it can cause ischemic stroke disease. The anti-thrombotic drugs commonly used are thrombolytics. These drugs contain fibrinolytic enzymes such as protease enzymes. Pineapple (Ananas comosus (L.) Merr) is known to have an an…
Background: Drug allergy is a hypersensitivity reaction to medications involving immunological mechanisms that can cause clinical manifestations ranging from mild to severe, such as rash, urticaria, and anaphylaxis. Children are a vulnerable group due to their immature immune systems and limited alternative treatment options. This study aimed to determine the distribution of drug allergy incide…
Background: Wound healing is a complex biological process that progresses through the phases of inflammation, proliferation, and remodeling. Cung kediro (Solanum lycopersicum var. cerasiforme) contains lycopene, β–carotene, vitamin C, and flavonoids, which act as potent antioxidants and have the potential to accelerate epithelialization, angiogenesis, and keratinization. This study aimed to …
Introduction: Oxidative stress is an imbalance between free radicals and endogenous antioxidants that plays a role in the pathogenesis of various degenerative diseases. Natural antioxidants from plants, particularly those containing phenolic compounds and flavonoids, have become potential alternatives for the prevention of oxidative stress. Kersen mistletoe leaves contain various secondary meta…
Diarrhea caused by Escherichia coli infections remains a significant public health problem in developing countries, including Indonesia. Overuse of antibiotics can lead to resistance, so alternatives are needed. Putat leaves (Barringtonia acutangula) contain the flavonoid quercetin, which has prebiotic and antibacterial potential. This study aims to investigate the effect of putat leaf extract …
Cefixime is a BCS class IV antibiotic characterized by low solubility and permeability, resulting in limited oral bioavailability. The L-SNEDDS system can improve drug solubility; however, it has limitations in liquid form, leading to the development of solid self-nanoemulsifying drug delivery system (S-SNEDDS). This study aimed to optimize cefixime-loaded S-SNEDDS using an adsorption method wi…
Erythromycin thiocyanate is a macrolide antibiotic classified under the Biopharmaceutical Classification System (BCS) class II, characterized by low solubility (±2 mg/mL) and approximately 17% oral bioavailability. This study aimed to optimize the formulation of liquid self-nanoemulsifying drug delivery system (L-SNEDDS) to enhance the dissolution of erythromycin thiocyanate and to further dev…
This study was motivated by the high risk of medication errors involving High Alert medicines, which can have serious implications for patient safety. Hospital pharmacy departments play a vital role in implementing a storage system for High Alert medicines in accordance with the National Patient Safety Standards (SNKP). This study aims to evaluate the compliance of High Alert drug storage at th…
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired insulin secretion or action. The increasing global prevalence of diabetes has encouraged the development of alternative therapies derived from natural products that are safer and more affordable. Miracle fruit (Synsepalum dulcificum) is traditionally used by the Penesak tribe in Ogan Ilir, S…
Background: Oral inflammation remains a common health problem in Indonesia. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) as conventional therapy is effective; however, long-term use may cause various side effects. Therefore, safer natural-based alternative therapies are needed. Gambir (Uncaria gambir Roxb.) is known to contain catechin compounds with anti-inflammatory activity. Obje…
Justicia secunda is a medicinal plant containing bioactive compounds whose composition is influenced by environmental conditions and cultivation practices. This study aimed to identify the metabolite profile of cultivated J. secunda leaves and evaluate their potential bioactivities. Extraction was carried out using 70% ethanol through the ultrasonic-assisted extraction (UAE) method, followed by…
Supit kijang (Tetracera indica) has the potential as an antidiabetic agent because it contains flavonoid compounds. This study aims to test the antidiabetic activity in vitro from the ethanol extract of Supit kijang stems. Extraction was carried out by maceration method on 100 grams of stem powder using 96% ethanol and produced a yield of 11%. The antidiabetic activity test was carried out in v…
The coverage of active family planning participants in Palembang City has not yet reached the national target and still has a relatively high unmet need rate. The availability of allocon as an enabling factor is suspected to play a role in the utilization of family planning services. This study aims to analyze the relationship between the availability of allocon and the prevalence of active fam…
This study is motivated by the high incidence of diseases transmitted by Culex sp. mosquitoes and the increasing resistance to chemical larvicides, highlighting the need for environmentally friendly control alternatives; therefore, it aims to evaluate the larvicidal activity of ethanol extract from lime leaves (Citrus aurantiifolia), determine the effective concentration, and calculate the LCâ‚…
Type 2 diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to insulin resistance and impaired pancreatic β-cell function. Red shoot leaves (Syzygium myrtifolium Walp.) contain active compounds such as phenolics and flavonoids with antidiabetic potential. This study aims to determine the compound groups of the ethyl acetate fraction of red shoot leaves, the effect of it…
The rising prevalence of type 2 diabetes mellitus (T2DM) indicates that this disease remains a health issue that requires serious attention. The long-term use of conventional therapies such as metformin may lead to adverse effects; therefore, alternative therapies based on natural products are needed. Pelawan leaves (Tristaniopsis merguensis Griff.) are known to contain bioactive compounds, par…
This report discusses the design of a Women and Children Hospoital in Palembang, driven by the high birth rate and the lack of attention to mothers’psychological well-being, including the risk of baby blues syndrome. The design adopts a Family-Centered Care (FCC) approach by involving family members in the healing process. It focuses on integrating spaces that support medical needs while also…
Diabetic ulcers are one of the chronic complications of diabetes mellitus, characterized by impaired wound healing due to prolonged inflammation, oxidative stress, and disrupted tissue regeneration. The complexity of their pathological mechanisms requires therapeutic strategies capable of targeting multiple molecular pathways at once, making the development of natural product–based therapies …
Multi drug resistance (MDR) is a major global health concern. Among MDRs, Methicillin-resistant Staphylococcus aureus (MRSA) has been classified by the World Health Organization (WHO) as priority nosocomial pathogen. The declining effectiveness of conventional antibiotics development the need for alternative strategies, such as antimicrobial photodynamic therapy (aPDT) and antimicrobial phototh…
Drug storage is a critical aspect of drug management in hospitals, as it ensures the quality, safety, and efficacy of drugs, during storage. Improper drug storage management can lead to expired, damaged, and dead stock drugs. This study aims to examine the relationship between storage compliance of High-Alert Medication (HAM) and expired, damaged, and dead stock drugs at Siti Fatimah General Ho…
Drug inventory control is an important part of hospital pharmaceutical services. Discrepancies between physical stock and system data can cause service disruptions and inefficiencies in drug management. This study aims to analyze discrepancies in the stock opname of prescription drugs and over-the-counter drugs and to identify the causative factors using the DMAIC (Define, Measure, Analyze, Imp…
Drug lanning is an essential stage in pharmaceutical management in hospitals to ensure the availability of medicine in accordance with healtcare service needs. One commonly used method is the consumption method, wich is based on drug usage data from pervious periods. Reseacrh of this study aims to evaluate the conformity between the planning of prescription-only medicine using the consumpetion …
Zaman dahulu, pengobatan menjadi aspek yang diutamakan oleh banyak orang untuk mencapai hidup sehat. Namun, sekarang orang cenderung memilih tindakan pencegahan, karena biaya yang dibutuhkan relatif lebih rendah.Tubuh dapat membuat sendir sebagian kecil zat gizi, tetapi sebagian besar tidak dapat dibuat di dalam tubuh sehingga harus diperoleh dari luar (makanan). Zat gizi jenis ini disebut zat …
This study aims to describe medicinal plants used by the people of the Besemah Clan (Semende Tribe, Sub Semende Darat) in Sindang Danau District, Ogan Komering Regency, South Ulu. This study uses a qualitative descriptive method which was carried out from November 2025 to March 2026. Data collection was carried out through field observation and interviews. Sampling was carried out purposively o…
Background: : Centella asiatica has long been used as a wound-healing agent due to its triterpenoid content, which possesses anti-inflammatory, antioxidant, and antifibrotic properties . During the wound healing process, TGF- β regulates re-epithelialization, inflammation, angiogenesis, and granulation tissue formation. Centella asiatica has been shown to decrease TGF-β 1, and contribute to t…
The development of information technology has driven the transformation of pharmaceutical services, one of which is the implementation of a website-based online drug sales system integrated with a management system and General Point of Sales (GPOS). This study aims to evaluate the implementation of a website-based online drug sales system using GPOS on the effectiveness of pharmaceutical servic…
Medication oversight in healthcare settings necessitates an organized and cohesive approach to enhance service effectiveness and ensure data precision. Klinik Su'adah Palembang is encountering obstacles in handling medication records due to the use of software with limited capabilities, which leads to challenges in ensuring stock accuracy, managing expired medications, and overseeing drug retur…