Pendahuluan: Talasemia beta mayor merupakan kelainan genetik yang ditandai dengan gangguan pembentukan rantai β-globin sehingga menyebabkan anemia berat yang memerlukan transfusi darah rutin seumur hidup. Transfusi darah berulang dapat menimbulkan kelebihan zat besi (iron overload) yang ditandai dengan meningkatnya kadar ferritin serum. Peningkatan kadar ferritin yang tidak terkontrol dapat me…
Background: Preterm delivery remains one of the leading causes of neonatal morbidity and mortality. One contributing factor is maternal iron status, particularly iron deficiency anemia (IDA). Hematological parameters such as Hb, MCV, MCHC, RDW, as well as the Mentzer and Green-King indices, can serve as early indicators of iron status disturbances in pregnant women. Methods: This descriptive cr…
Background: Beta-thalassemia major is a hereditary blood disorder characterized by impaired hemoglobin production, requiring lifelong regular blood transfusions. Iron overload, measured by serum ferritin levels, and nutritional problems are major complications that affect patients’ quality of life. This study aimed to analyze the relationship between serum ferritin levels and nutritional stat…
Pediatric transfusion-dependent thalassemia patients require lifelong transfusion to compensate for inadequate erythrocyte and to support patient’s growth and development. However, regular transfusion can cause iron overload leading to oxidative stress-induced liver injury. The purpose of this study is to analyze the relationship between iron overload and liver function in pediatric transfusi…