Background: Diabetic wounds are characterized by persistent inflammation, impaired angiogenesis, and delayed epithelialization. Anredera cordifolia (binahong) contains flavonoids, saponins, and triterpenoids with antioxidant and antibacterial activities. However, the molecular mechanisms of binahong in modulating GM-CSF expression and histological improvement based on the HEALS-A score have not…
Background: Hydatidiform mole is part of the spectrum of gestational trophoblastic disease and may progress to gestational trophoblastic tumor (GTT). This progression is thought to be associated with dysregulation of cell proliferation, cell-cycle control, and apoptosis. Molecular biomarkers such as Vitamin D Receptor (VDR), Ki-67, p21, p27, p63, and Bcl-2 are involved in oncogenic signaling pa…
Introduction: Sepsis is a leading cause of morbidity and mortality in critically ill patients. While estradiol administration shows potential as a sepsis therapy, its impact on the necroptosis process remains unclear. This study aims to investigate the effect of estradiol administration on necroptosis and inflammation in a sepsis-induced Wistar rat model. Methods: This experimental study employ…