Sambiloto leaf extract (Andrographis paniculata) contains secondary metabolites, one of which is flavonoid. Flavonoid have a special compound, quercetin, which has the potential to stimulate probiotic and antibacterial activity. The extract has a bitter taste so that it is formulated in the form of orally dissolving film (ODF) preparation which is expected to cover the bitter taste and provide …
Andrographis paniculata (Burm.f.) Nees) contains andrografolid, a compound that has anti-inflammatory, antibacterial, and antioxidant activities to accelerate burn wound healing. This study evaluated the preparation of submicro emulsion of bitter melon leaf extract with Tween 20 and PEG-400 at a concentration of 10% and tested the burn wound healing activity in Wistar rats. This study was divid…
Sambiloto has secondary metabolite compounds that are active as anti-inflammatory, antioxidant and antibacterial which have the potential to be developed into sub-microemulsion preparations for burns. This study aims to provide a sub-microemulsion preparation of sambiloto leaf extract (Andrographis paniculata) with a combination of Tween 80 and PEG-400 as an innovative preparation and burn acti…
Sambiloto leaves (Andrographis paniculata (Burm. F) Wall. Ex Ness) contain secondary metabolites with antibacterial, anti-inflammatory, and antioxidant activities, making them a potential agent for burn wound healing. This study evaluated a 1% submicron emulsion of sambiloto leaf extract prepared with a combination of Tween 80 and ethanol at a 25% concentration, testing its burn wound healing a…
Inflammation is the body's protective mechanism against tissue damage caused by physical trauma, chemical irritation, or microbial infection. However, the use of synthetic anti-inflammatory drugs, such as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), often leads to side effects, including gastrointestinal irritation and impaired kidney function. Sambiloto (Andrographis paniculata) is an herba…
Bitter leaf extract (Andrographis paniculate (Burm.f) Wall. Ex Ness) contains secondary metabolites andrographolide and quercetin which have potential antibacterial activity. This research aims to determine the nanoemulsion formulation with a combination of Tween 80 and Ethanol 96% concentration on the activity of Propionibacterium acnes and the stability of ICH Q1A (R2). Data analysis in this …
Sambiloto leaves (Andrographis paniculate (Burm. F) Wall ex. Ness) contain andrografolid and flavonoids as the main compounds that have potential as antibacterial. Nanoemulsion with a combination of tween 20 and PEG-400 was carried out to produce preparations that have better antibacterial effects and are thermodynamically stable. This study was conducted to determine the characteristics and st…
The endophytic microorganism is a form of bacteria or a fungi microorganism that form colonies interiororgans of plants, but does not harm the host plant. The secondary metabolites compound heve been isolated from endophytic fungi (Aspergillus flavus) living in symbiotic dill for malaria that is sambiloto ( Andrographis paniculata Nees ). Isolation begin with cultivation of Aspergillus flavus f…
Telah berhasil diisolasi senyawa metabolit sekunder dari jamur endofitik Aspergillus sp2 pada daun tumbuhan Sambiloto (Andrographis paniculata nees). Isolasi senyawa diawali dari kultivasi menggunakan media PDB (Potato Dextrose Agar) sebanyak 9 L dengan masa inkubasi selama 41 hari. Senyawa yang terdapat dalam medium kultur cair diekstraksi secara partisi menggunakan etil asetat, dievaporasi da…