Tithonia diversifolia is a shrub belonging to the Asteraceae family and one of 12 species classified under Tithonia genus. T. diversifolia is known in Indonesia as kipait, paitan, kembang bulan, and insulin. Previous studies have reported that T. diversifolia contains abundant sesquiterpene lactones compounds. Sesquiterpene lactones have been extensively reported in the aerial parts of T. diver…