Thalassemia is a genetic blood disorder that requires lifelong management, including regular blood transfusions and iron chelation therapy. This condition affects the quality of life of children, which is strongly influenced by their parents’ level of knowledge in providing care. This study aimed to determine the relationship between parents’ level of knowledge and the quality of life of ch…
Background: Beta-thalassemia major is a hereditary blood disorder characterized by impaired hemoglobin production, requiring lifelong regular blood transfusions. Iron overload, measured by serum ferritin levels, and nutritional problems are major complications that affect patients’ quality of life. This study aimed to analyze the relationship between serum ferritin levels and nutritional stat…
Thalassemia is a genetic disorder with a high prevalence in Indonesia. Prevention through premarital screening and genetic counseling is essential to reduce the prevalence of this disease. As future medical professionals, medical students are expected to possess adequate knowledge about premarital screening and genetic counseling to support thalassemia prevention. This study aims to identify th…
Background: Pediatric thalassemia major require lifelong blood transfusions to compensate inadequate erythrocyte. However, regular blood transfusions cause iron overload. In addition, pathologically in thalassemia, there is also iron accumulation due to faster hemolysis and ineffective erythropoiesis process. Iron overload is toxic for organ so that it must be removed using iron chelation, one …
Thalassemia is a genetic disorder caused by defects in the production of one or more globin subunits of hemoglobin. In thalassemia major, patients are prone to hemolysis and require regular blood transfusions. Hemolysis and routine blood transfusions can lead to iron accumulation in the body, resulting in elevated ferritin levels, the main iron storage protein. High ferritin levels indicate exc…
Latar Belakang: Thalassemia beta mayor merupakan gangguan pembentukan hemoglobin yang membutuhkan penatalaksanaan transfusi darah rutin seumur hidup. Peningkatan kadar feritin serum digunakan sebagai salah satu indikator penilaian risiko iron overload yang merupakan akibat dari penatalaksanaan transfusi darah berulang tersebut. Hal ini berkaitan dengan gangguan pertumbuhan yang dapat terjadi ka…
Background: Thalassemia is a hereditary blood disorder in which a genetic mutation occurs which causes reduced or absent globin chains in the hemoglobin of red blood cells. According to the Indonesian Ministry of Health in 2019, Indonesia is estimated to have 3.8% carriers of the thalassemia gene and there are around 1500 new cases every year. As the number of thalassemia patients increases, it…
Background: Thalassemia is a genetic condition caused by mutations in the globin gene, leading to a decrease or absence of alpha globin chains in alpha thalassemia or beta globin chains in beta thalassemia. This results in suboptimal formation of red blood cells, leading to anemia in patients, necessitating blood transfusions. Regular blood transfusions result in an excess of iron in the body. …
Background: Thalassemia is a genetic disorder characterized by the absent or decreased production of α and β-globin chains. Beta-thalassemia patients usually have growth retardation, especially of the condyles and the ramus of the mandible, which can cause malocclusion. Malocclusion in beta-thalassemia patients can be treated with orthodontic treatment by considering cephalometric analysis, w…
Background: Thalassemia is a hemolytic disease that is inherited as autosomal recessive form disturbance synthesis globin chain up to occur decline cell blood redness and chronic anemia and must blood transfusion and, iron chelation therapy is needed. Assistance during therapy causes psychosocial disorders of parents and influences the occurrence of depression. The aim of this study was to dert…
Latar Belakang: Thalassemia merupakan genetik autosomal resesif karena kelainan pada gen pengkode protein globin. Hal tersebut menyebabkan gangguan sintesis globin berupa tidak ada atau menurunnya rantai yang membentuk struktur hemoglobin sehingga hemoglobin tidak terproduksi dengan baik. Penderita thalassemia anak mengalami ketidak efektifan dalam proses eritropoiesis dan percepatan penghancur…
Background: Thalassemia is a group of hemolytic diseases from genetic disorders resulting from a decrease in the synthesis of alpha or beta chains of hemoglobin (Hb). A particular craniofacial cephalometric picture is found in the form of mild skeletal class II clinical manifestations. The anterior cranial base becomes a benchmark or reference sector in the measurement of dentofacial structures…
Latar Belakang: Thalassemia adalah kelainan bawaan yang terjadi akibat gangguan pada sintesis hemoglobin. Indonesia sendiri kasus thalassemia diperkiraan memiliki angka kelahiran 2.500 anak dengan thalassemia setiap tahunnya. Pada pasien thalassemia sering ditemukan kelainan skeletal kelas 2. Sudut interinsisal merupakan sudut yang dibentuk dari perpotongan sumbu gigi incisivus rahang atas dan …
Thalassaemia is a congenital haemolytic anemia, caused by lack of synthesis of globin chains that construct polypeptide in the haemoglobin molecules. Patients with thalassaemia have a distinctive facial characteristic, which is known as chipmunk face in which the patient's face looks like a Mongoloid. This characteristic is often accompanied by an excessive maxillary growth. This condition can …
Background: Thalassemia is an inherited disorder syndrome (inherited). Thalassemia is a disease among the groups most hemolytic anemia. Thalassemia major is a serious blood disease and until now there is no medicine that can cure thalassemia major in total. Thalassemia is a genetic disease that affects the lifetime and throughout his life the patient must take medication or therapy on a regular…
Background: Thalassemia is a hereditary disease that in general there is a deceleration in hemoglobin synthesis. Thalassemia patients need to receive blood transfusion regularly to blood hemoglobin. mcrease However, patients will need various blood amount in each individual. Objectives: This aim of this study is to determine the need for blood transfusion based on clinical characteristics of pa…
Thalassemia merupakan penyakit kelainan hemoglobin yang dapat memberikan manifestasi gangguan pada tumbuh kembang. Penyebab gangguan tumbuh dan kegagalan pubertas masih bersifat multifaktorial namun faktor-faktor yang berpengaruh masih belum diketahui dengan pasti. Penelitian ini bertujuan untuk mengetahui status pertumbuhan dan pubertas serta hubungan faktor risiko (usia, jenis kelamin, hemogl…
Thalassemia and iron deficiency anemia are blood disorders characterized by paleness and fatigue. In Indonesia, the prevalence of th alassemia is around 3 while the prevalence of iron deficiency anemia is around 40-- 10%, 50%. With the high prevalence of thalassemia and iron deficiency anemia, it is very important for medical students to know about thalassemia and iron deficiency anemia. The pu…