Background: Periodontal disease is one of the dental and oral health problems with a fairly high percentage in Indonesia. One of the microorganisms that plays a role in periodontal disease is the bacterium A. actinomycetemcomitans. Catfish (Pangasius sp) as the most cultivated in South Sumatra is reported to have amino acid content that has the potential to be antibacterial. Objective: To deter…