Background: Indonesia ranks 7th out of 10 countries in the world with the highest number of people with diabetes. In type 2 DM TNF-α contributes to the development of insulin resistance, which accounts for 90-95% of cases of this disease. Karamunting (Rhodomyrtus tomentosa) is one of the plants that has medicinal value, with more than 100 compounds, Quercetin is one of the compounds that has a…