Microplastics and heavy metals are pollutants that can pollute a water area. Microplastics and heavy metals also have effects that can disrupt enzyme activity in the body of biota. This study aims to analyze the effects of single polypropylene (PP) microplastics, single cadmium (Cd) heavy metals, and their combination on protease enzyme activity in blood cockles (Anadara granosa). Blood cockle …