Background: Periodontal disease is one of the most common dental and oral health problems in Indonesia. One of the microorganisms that play a role in periodontal disease is the bacterium Porphyromonas gingivalis (P. gingivalis). Catfish (Pangasius sp) as the most cultivated fish in South Sumatra is reported to contain fatty acids and amino acids that have the potential as antibacterial. Objecti…