Plasmodium falciparum causes of severe malaria or cerebral malaria and main cause of the death in malaria case. Malaria still as a health problem in tropic and subtropic countries and also in Indonesia. Malaria caused by Plasmodium falciparum is many appeared in endemic region in Indonesia. In most of region still use Chloroquine as a first line and the combination Sulfadoxine-Pyrimetamine as a…