Jackfruit leaf extract (Artocarpus heterophylus Lam.) was used as an active substance in acne treatment. Secondary metabolites contained flavonoids, saponins and tannins which have antibacterial activity. Flavonoids are thermolabile and easily oxidized so ethanol extract of jackfruit leaves is made in form of submicro particles. Micro particle jackfruit leaf extract with a size 5,485 microns we…