Background: Diffuse Large B Cell Lymphoma (DLBCL) is a malignancy derived from malignant transformation of B cells from the germinal center. This type of non-Hodgkin's lymphoma is the most common and represents about 30-40% of all cases. The tumor microenvironment of B-cell lymphoma plays an important role in the regulation of tumor cell survival and proliferation. Plasma cells in the tumor mic…