Acne vulgaris is often a skin problem that can be caused by the bacteria Propionibacterium acnes. A natural ingredient that can inhibit the growth of P. acnes bacteria is Thymoquinone which is contained in black cumin oil. A combination of HPMC as a gelling agent and black cumin oil as an anti-acne with 3 kinds of formulas with different concentrations of HPMC and black cumin. The aim of this r…