Catfish (Clarias gariepinus) is one type of freshwater fish that is favored by the community. Constraints in catfish farming are disease attacks. One of the diseases that often attack is Motile Aeromonas Septicemia (MAS). Chromolaena odorata is a wild plant that is considered a weed has antibacterial properties and is able to ward off free radicals. This study aimed to determine the effect of s…