Background : Indonesia was ranked 5th worldwide regarding diabetic patients with a total number of 19,5 millions, and is expected to increase by around 21.3 millions by 2045. 90% of the case is a Type 2 Diabetes Mellitus that were caused by insulin resistance, which can be triggered by IL-6. Karamunting (Rhodomyrtus tomentosa) is a plant that often be used as a herbal medicine. Quercetin is one…