Background: Denture stomatitis is a chronic infection that caused by Candida albicans that occurs in 15% to 65% people who wear full or partial denture. The aim ofthis research was to evaluate the effect of extract cacao (Theobroma cacao) seed in inhibiting the growth of C.albicans. Method: This research was conducted by using multilevel maceration techniques with n-hexane, ethyl acetate, and e…