Clindamycin HCl in conventional topical formulation has a problem in its formulation. It has low bioavalilability, just around 5-8% from total concentration that can be absorbed. In addition, clindamycin HCl also difficult to penetrate into stratum corneum of the skin while Propionibacterium acnes is a bacterium that resides in the sebaceous area of the skin. To overcome this problem, it is nec…