Chayote leaves (Sechium edule (Jacq.) Swartz) contain secondary metabolites like flavonoids, tannins, and saponins acting as antidiabetic agents through beta-cell protection. This study aimed to determine the antidiabetic activity of the ethanolic extract of chayote leaves (EECL) and evaluate its effect on pancreatic histopathology in hyperglycemic male Wistar rats. Hyperglycemia was successful…