Background: Streptococcus mutans is a Gram-positive bacterium that is known as the main pathogen of dental caries. The use of chlorhexidine gluconate as an antibacterial agent can reduce Streptococcus mutans colonies, but if used for a certain period it can irritate the oral mucosa, change in tooth color, and changes in taste perception. Therefore, pineapple leaf as a natural ingredient are use…