Carica papaya is known to reduce the quality of spermatozoa in rats. Papaya seed formulation in the form of SNE (Self-Nano Emulsion) is an alternative drug delivery system to increase bioavailability by lipophilic means. Papaya seed extract was characterized using GC-MS to see the compounds contained therein. Papaya seed extract was formulated into Self-nano emulsion and evaluated including pH,…