A research regarding formulation and optimization of gel from erythromycin submicro particles using gelling agent HPMC 60-SH has been conducted. The concentration of HPMC 60-SH was used 2% for first formula, 4% for second formula, and 6% for third formula. Based of the observation result showed that HPMC 60-SH 2% has been produced a gel with highest quality than any other formula. The test resu…