Mangosteen peel extract (Garcinia mangostana L.) has alpha mangostin compounds that have very strong antioxidant activity. Transethosomes have better vesicle elasticity and penetration levels so that they can increase the effectiveness of alpha mangostin. This study aims to determine the optimum formula of transethosomes from variations of 96% ethanol concentrations of 20% and 40% with tween 80…