This study aims to determine the antibacterial activity of ethanol extract of harendong bulu leaves (Clidemia hirta) against the growth of Streptococcus pyogenes bacteria and Minimum Inhibitory Concentration (MIC). The research method used is an experimental method with a completely randomized design (CRD) with 5 treatments and 5 repetitions and data were analyzed using One Way ANOVA Test and c…