Clindamycin HCl has problem of penetration into the skin, only 1% to 3% of the applied dose of clindamycin HCl can be absorbed into the skin for 24 hours so that ethosomes are expected to be a delivering clindamycin HCl in penetration into the skin with the ability to fusion with skin lipids and high deformability. This study aims to optimize the ethosomes formula for clindamycin HCl with varia…