Background: Xanthine oxidase is an enzyme that catalyzes the formation of uric acid. Secondary metabolites that have a potential as xanthine oxidase inhibitor or antihyperuricemia are flavonoids, alkaloids, terpenoids, saponins, and tannins. From the latest research, ethanol extract of the stem of kayu kuning contains secondary metabolites such as flavonoids, alkaloids, terpenoids, saponins, an…