This study aimed to evaluate the antihyperlipidemic activity of the ethanolic extract of chayote leaves (Sechium edule (Jacq.) Swartz) in male Wistar rats induced with a high-fat and fructose diet. The induction was performed to establish a hyperlipidemic condition characterized by increased total cholesterol and LDL levels, along with decreased HDL levels. This study also assessed the effect o…