This study aims to group 17 regencies/cities in South Sumatera based on the characteristics of the cluster level COVID-19 spread. Grouping in three periods was carried out to determine the development of the spread of COVID-19 cases. The period used is period 1 (September-December 2020), period 2 (January-April 2021), and period 3 (May-August 2021). Grouping is carried out with K-Means Cluster …