Background: Hypercholesterolemia is a condition when total cholesterol increases beyond its normal value (≥200 mg/dL). Hypercholesterolemia is the main cause of atherosclerosis in blood vessels, such as in peripheral arterial disease, myocardial infarction, and stroke. The most commonly antihypercholesterolemia drug that used in Indonesia is simvastatin. Irrational use of medicine is still th…